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Name | 5-hydroxytryptamine receptor 2C |
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Species | Rattus norvegicus (Rat) |
Gene | Htr2c |
Synonym | 5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV |
UniProt | P08909 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL324 |
IUPHAR | 8 |
DrugBank | BE0004882 |
Name | amoxapine |
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Molecular formula | C17H16ClN3O |
IUPAC name | 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine |
Molecular weight | 313.785 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.6 |
Synonyms | Prestwick0_000102 s4218 SPECTRUM2300161 SR-01000003001-4 Z1551429736 [ Show all ] |
Inchi Key | QWGDMFLQWFTERH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 |
PubChem CID | 2170 |
ChEMBL | CHEMBL1113 |
IUPHAR | 201 |
BindingDB | 22870 |
DrugBank | DB00543 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.99 nM | PMID7908055 | BindingDB |
Ki | 1.99526 nM | PMID8876023 | IUPHAR |
Ki | 2.0 nM | PMID8876023 | BindingDB |
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