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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	6-Methoxytryptamine
Molecular formula	C11H14N2O
IUPAC name	2-(6-methoxy-1H-indol-3-yl)ethanamine
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.5
Synonyms	RD-0135 VOCGEKMEZOPDFP-UHFFFAOYSA-N 2-(6-METHOXY-1H-INDOL-3-YL)ETHAN-1-AMINE 6-methoxy tryptamine AB00465 AX8013240 ChemDiv2_004125 FT-0621205 M-3560 NCGC00163351-01 SCHEMBL379337 ZINC77360 2-(6-methoxyindol-3-yl)ethylamine 6-Methoxytryptamine, 99% ACM2736212 CBDivE_000653 DB-048919 I05-3298 PDSP2_001680 STL281843 2-(2-Aminoethyl)-5-methoxyindole 610M364 ALBB-021005 EU-0011857 KB-69766 SBB000286 VZ30813 2-(6-methoxy-1H-indol-3-yl)ethanamine AB0076679 BDBM50028124 CM-339 GS-3335 MCULE-1065608717 Oprea1_535398 ST24027592 ZX-AN036619 1H-INDOLE-3-ETHANAMINE, 6-METHOXY- 3-(2-Aminoethyl)-6-methoxyindole 6-Methoxytryptamine, analytical standard AJ-10408 CC-22856 DTXSID80189680 IDI1_002840 PubChem24288 TC-135466 2-(6-Methoxy-1H-indol-3-yl)-ethylamine 6-MeOT A6266 ANW-46721 CHEMBL337825 FCH932054 KS-000025XF MolPort-001-788-579 SC-78655 W-6181 2-(6-methoxy-1H-indol-3-yl)ethylamine 6-Methoxytryptamine hydrochloride AC1L2AEH C-08111 CTK4H5895 HMS1380L11 PDSP1_001697 ST45021221 1H-Indole-3-ethanamine,6-methoxy- 3610-36-4 6-Methoxytryptamine, free base AKOS000265357 CCG-112234 EINECS 222-778-2 Jsp006451 [ Show all ]
Inchi Key	VOCGEKMEZOPDFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3
PubChem CID	17654
ChEMBL	CHEMBL337825
IUPHAR	N/A
BindingDB	50028124
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	36.3 nM	PMID7647964	BindingDB
Ki	363.07 nM	PMID7647964	BindingDB

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