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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Clorotepine
Molecular formula	C19H21ClN2S
IUPAC name	1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine
Molecular weight	344.901
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.3
Synonyms	1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine AC1Q3SXZ Clorotepina clorothepin Lopac0_000885 OCTOCLOTHEPIN,(-) BRD-A19053834-050-06-1 CLOROTEPINE (+) clothepine NCGC00015759-03 PDSP2_001530 8-chloro-10-(4-methyl-1-piperazinyl)-10,11-dihydrodibenzo(b,f)thiepin Clorotepinum FT-0746338 Octoclothepin maleate VUFB-6281 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methylpiperazine 1-{6-chloro-2-thiatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-9-yl}-4-methylpiperazine AKOS005065436 Clorotepina [INN-Spanish] Clotepin LS-111082 Octoclothepine 42505-79-3 (monomethanesulfonate salt) CCG-204967 Clorotepine [INN] D0D3YN NCGC00162287-01 Piperazine, 1-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methyl- 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine AC1L1B15 CHEMBL64249 Clorotepinum [INN-Latin] L000790 OCTOCLOTHEPIN,(+) XRYLGRGAWQSVQW-UHFFFAOYSA-N 1-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methylpiperazine 13448-22-1 BDBM22872 Clothepin NCGC00015759-02 PDSP1_001546 4789-68-8 (2-maleate salt) CHEBI:135459 CLOROTEPINE(-) DTXSID7048451 Octoclothepin SCHEMBL678917 1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)-4-methyl-piperazine;maleate [ Show all ]
Inchi Key	XRYLGRGAWQSVQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21ClN2S/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19/h2-7,13,17H,8-12H2,1H3
PubChem CID	1238
ChEMBL	CHEMBL64249
IUPHAR	N/A
BindingDB	22872
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.51 nM	PMID7647964	PDSP,BindingDB
Ki	32.35 nM	PMID7647964	PDSP,BindingDB

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