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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Pirenperone
Molecular formula	C23H24FN3O2
IUPAC name	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one
Molecular weight	393.462
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.6
Synonyms	NCGC00015784-07 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one(Pirenperone) NCGC00021326-04 AC1Q2F2M Opera_ID_1876 BSPBio_003409 Pirenperone [USAN:INN:BAN] CPD000058507 Prestwick_858 DTXSID9045182 SBI-0050980.P003 HMS2093C08 Spectrum3_001655 KBio1_001703 Tox21_110220 Lopac-P-126 MolPort-003-666-539 3-[2-[4-(4-Fluorobenzoyl)-1- piperidinyl]-ethyl-2-methyl-4H- pyrido[1,2-a]pyrimidin-4-one 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one NCGC00015784-10 4H-Pyrido[1,2-a]pyrimidin-4-one,3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl- NCGC00178084-01 BDBM50024205 Pirenperona CAS-75444-65-4 Pirenperonum [INN-Latin] D05495 R-47,465 FT-0732988 SPBio_001899 HMS3263I15 Spectrum_001584 KBio2_007200 UNII-Y9FMC4513X LS-177186 NCGC00015784-02 3-[2-[4-(p-fluorobenzoyl)piperidino]ethyl]-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one NCGC00015784-14 AB00053292_16 NSC-760095 BRD-K25224017-001-15-1 Pirenperone (USAN/INN) Prestwick2_000531 DSSTox_GSID_45182 R-50656 HMS1922F15 SPECTRUM1504188 HMS3713L03 SR-01000002998-5 KBioSS_002064 MLS001148188 3-(2-(4-(4-fluorobenzoyl)piperidino)ethyl)-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one NCGC00015784-05 NCGC00015784-08 3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-methylpyrido[1,2-a]pyrimidin-4-one NCGC00021326-05 AC1Q4NIA P-126 C23H24FN3O2 Pirenperone, >97%, solid CTK5E1570 R 47456 EINECS 278-213-5 SCHEMBL467209 HMS2096L03 Spectrum4_000620 KBio2_002064 Tox21_110220_1 Lopac0_001007 NC00316 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]-ethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one ZINC538194 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one NCGC00015784-11 NCGC00178084-02 BPBio1_000597 Pirenperona [INN-Spanish] CCG-39087 Prestwick0_000531 DivK1c_006759 R-47456 GTPL283 SPBio_002462 HMS3370M02 SR-01000002998 KBio3_002629 VU0239628-6 MFCD00069332 NCGC00015784-03 NCGC00015784-06 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one NCGC00021326-03 AC1L1J38 NSC760095 BSPBio_000541 Pirenperone [USAN:BAN:INN] CHEMBL18331 Prestwick3_000531 DSSTox_RID_80730 SAM001246893 HMS2051H22 Spectrum2_001680 HXCNRYXBZNHDNE-UHFFFAOYSA-N SR-01000002998-7 L000956 MLS001424212 3-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one NCGC00015784-09 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-2-methyl- NCGC00021326-06 AKOS030530791 Pharmakon1600-01504188 CAS- 75444-65-4 Pirenperonum D00PEU R 50656 EU-0101007 SMR000058507 HMS2234F07 Spectrum5_001827 KBio2_004632 Tox21_501007 LP01007 NCGC00015784-01 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-methylpyrido[2,1-b]pyrimidin-4-one NCGC00015784-12 75444-65-4 NCGC00261692-01 BRD-K25224017-001-05-2 CHEBI:92444 Prestwick1_000531 DSSTox_CID_25182 R-47465 HMS1569L03 SpecPlus_000663 HMS3393H22 SR-01000002998-2 KBioGR_001180 Y9FMC4513X MLS000069365 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one NCGC00015784-04 [ Show all ]
Inchi Key	HXCNRYXBZNHDNE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
PubChem CID	4847
ChEMBL	CHEMBL18331
IUPHAR	283
BindingDB	50024205
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
126059	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
126066	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
126061	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
126069	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
126065	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
126072	5-hydroxytryptamine receptor 2B	P30994	Htr2b	Rattus norvegicus (Rat)	479
126070	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
126067	5-hydroxytryptamine receptor 7	P50407	HTR7	Cavia porcellus (Guinea pig)	446
553921	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
126060	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
126063	Alpha-2C adrenergic receptor	P22086	Adra2c	Rattus norvegicus (Rat)	458
126068	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
126064	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
126071	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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