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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	D-Lysergic acid N,N-diethylamide
Molecular formula	C20H25N3O
IUPAC name	N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight	323.44
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	D-LSD-25 L000352 VAYOSLLFUXYJDT-UHFFFAOYSA-N Acid [Street Name] Dextrolysergic Acid diethylamide N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, (8.beta.)- # (+)-LSD COS0000448 Heavenly Blue [Street Name] Royal Blue [Street Name] 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-.beta.-carboxamide d-Lysergic acid dethylamide Lysergsaure diethylamid Wedding bells [Street Name] BDBM86427 Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8.beta.)- NSC_3981 Cubes [Street Name] Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv. SCHEMBL12401704 AC1L1H5B Lysergsaure-N,N-diethylamid CAS_50-37-3 Ergoline-8.beta.-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- Pearly gates [Street Name] [ Show all ]
Inchi Key	VAYOSLLFUXYJDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3
PubChem CID	3981
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.398107 nM	PMID10051134	PDSP
Ki	15.48 nM	PMID7647964	PDSP
Ki	30.9 nM	PMID7647964	PDSP

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