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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	prochlorperazine
Molecular formula	C20H24ClN3S
IUPAC name	2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Molecular weight	373.943
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.9
Synonyms	BC224538 NCGC00015856-03 Buccastem Nipodal Phenothiazine, 2-chloro-10-[3-(1-methyl-4-piperazinyl)propyl]- cid_91499 Probes1_000265 Compro (TN) Emelent 121422-EP2298313A1 I06-1771 2-Chloro-10-[3-(4-methyl-1-piper- azinyl)propyl]-10H-pheno-thiazine dimaleate KBio2_007440 2-chloro-10-[3-(4-methylpiperazino)propyl]phenothiazine;ethane-1,2-disulfonic acid L001030 AB00053532 MLS001148133 Prochlorperazine dihydrobromide Prochlorpermazine SBI-0051005.P004 Spectrum3_000881 STL371212 MRF-0000068 BRD-K19352500-070-02-5 NCGC00015856-06 C20H24ClN3S NSC17478 Chlormeprazine Prestwick0_000399 Compazine 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- Eskatrol (Salt/Mix) 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine KBio2_001320 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine KBioGR_001343 58-38-8 LS-105399 AC1L1J8I UNII-YHP6YLT61T Prochlorperazine mesilate Proclorperazina SMR000058705 Spectrum_000840 NCGC00015856-01 BSPBio_000617 NCI60_022783 CCG-205112 Pasotomin Chloropernazine Prestwick3_000399 Compazine Suppositories DTXSID7023514 118276-EP2298764A1 HMS2231P21 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine KBio2_004872 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine KBioSS_002306 Meterazine API0003935 YHP6YLT61T Prochlorperazinum RP 6140 SPBio_002538 Stemetil (TN) BDBM78434 NCGC00015856-04 Buccastem (TN) Novamin CHEMBL728 Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- cMAP_000013 Probes2_000307 D00493 058P388 Emetiral 2-chloranyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine IDI1_000413 2-Chloro-10-[3-(4-methyl-1-piper-azinyl)propyl]-10H-pheno-thiazine dimaleate KBio3_001762 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine Lopac-P-9178 AB00053532_29 MLS006011830 Prochlorperazine Edisylate Salt Prochlorpromazine SCHEMBL18429 Spectrum4_000972 Tementil N-(.gamma.-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine BRD-K19352500-070-05-8 NCGC00015856-07 Capazine Opera_ID_244 Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine Prestwick1_000399 Compazine (Maleate) DB00433 118276-EP2275420A1 FT-0603243 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine KBio2_002304 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;ethane-1,2-disulfonic acid KBioGR_002304 6140 R.P. Meterazin AKOS003600762 Vertigon Prochlorpemazine Prochlorperazine [USAN:INN:BAN:JAN] Proclorperazina [INN-Spanish] SMR000653454 SR-01000000260-11 Bayer A 173 NCGC00015856-02 BSPBio_002394 NINDS_000413 CHEBI:8435 Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)- Chlorperazine Proazine Compro EINECS 200-379-4 118276-EP2298765A1 HSDB 3171 2-chloro-10-(3-(4-methylpiperazin-1-yl)propyl)-10h-phenothiazine KBio2_006456 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;ethane-1,2-disulfonic acid Kronocin A831861 MLS000028600 ZINC19796018 Prochlorperazine (JAN/USP/INN) Prochlorperazinum [INN-Latin] RP-6140 Spectrum2_001297 Stemzine (TN) BPBio1_000679 NCGC00015856-05 C07403 NSC167375 CHLOPERAZINE Phenotil (TN) Combid Prochloroperazine D0B2UZ 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)- Eskatrol 2-chloranyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;ethane-1,2-disulfonic acid KBio1_000413 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine # KBio3_002784 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine Lopac0_001034 AB00053532_30 MolPort-001-611-821 Prochlorperazine maleate Procloperazine SKF 4657 Spectrum5_001339 Temetid N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine BRD-K19352500-332-03-7 NCGC00023036-03 CAS-84-02-6 P77 Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French] Prestwick2_000399 Compazine (TN) DivK1c_000413 118276-EP2298313A1 GTPL7279 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine KBio2_003888 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine KBioSS_001320 6140 RP Meterazin maleate AN-41754 WIKYUJGCLQQFNW-UHFFFAOYSA-N Prochlorperazin Prochlorperazine [USP:INN:BAN:JAN] Proclorperazine SPBio_001333 Stemetil [ Show all ]
Inchi Key	WIKYUJGCLQQFNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
PubChem CID	4917
ChEMBL	CHEMBL728
IUPHAR	N/A
BindingDB	78434
DrugBank	DB00433
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID7647964	PDSP,BindingDB

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