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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	5-Benzyloxytryptamine
Molecular formula	C17H18N2O
IUPAC name	2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine
Molecular weight	266.344
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.0
Synonyms	5-BT AN-7305 CB-249 EU-0045275 LS-82273 R1244 ZINC57128 1H-Indole-3-ethanamine, 5-(phenylmethoxy)- 2-[5-(benzyloxy)-1H-indol-3-yl]ethanamine hydrochloride 5-(Phenylmethoxy)-1H-indole-3-ethylamine monohydrochloride 5-benzyloxy-tryptamine A-7289 B19458 CHEMBL1288652 HMS2808A18 MolPort-001-779-632 SMR000437938 2-(5-Benzyloxy-1H-indol-3-yl)-ethylamine 2-[5-(phenylmethoxy)-1H-indol-3-yl]ethanamine AKOS001676606 BDBM82302 EINECS 244-024-1 KB-177042 PDSP1_000769 TR-018512 2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine 5-BZT AS-47706 CBDivE_004615 FT-0620055 MCULE-8280916549 SBB003066 ZX-AN006412 1H-Indole-3-ethanamine,5-(phenylmethoxy)- 2-[5-(Benzyloxy)-1H-indol-3-yl]ethylamine 5-benzyloxy tryptamine 5-Benzyloxytriptamine AC1L3I5U BB 0242425 CTK4E5072 Jsp004257 NCGC00246513-01 ST50308182 2-(5-benzyloxy-1H-indol-3-yl)ethanamine 2-[5-(phenylmethoxy)indol-3-yl]ethylamine 5-Benzyloxytryptamine, free base ALBB-006771 CAS_20776-45-8 EINECS 257-626-4 L000876 PDSP2_000757 WKPDXBXNJWWWGQ-UHFFFAOYSA-N 2-[5-(benzyloxy)-1H-indol-3-yl]ethanamine 3-(2-aminoethyl)-5-benzyloxyindole B-2100 CCG-20533 GTPL265 MLS000762453 SCHEMBL2537373 2-(5-(Benzyloxy)-1H-indol-3-yl)ethanamine 2-[5-(Benzyloxy)-1H-indol-3-yl]ethylamine # 5-Benzyloxy-3-(2-ethylamino)indole hydrochloride 5-Benzyloxytriptamine HCl AJ-09599 BBL001424 D06NGQ KB-163149 Oprea1_485666 STK500562 2-(5-benzyloxy-1h-indol-3-yl)ethylamine 20776-45-8 [ Show all ]
Inchi Key	WKPDXBXNJWWWGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18N2O/c18-9-8-14-11-19-17-7-6-15(10-16(14)17)20-12-13-4-2-1-3-5-13/h1-7,10-11,19H,8-9,12,18H2
PubChem CID	89576
ChEMBL	N/A
IUPHAR	265
BindingDB	82302
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	257.03 nM	PMID7647964	PDSP,BindingDB
Ki	1096.47 nM	PMID7647964	PDSP

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