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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Dipropyl-5-CT
Molecular formula	C17H25N3O
IUPAC name	3-[2-(dipropylamino)ethyl]-1H-indole-5-carboxamide
Molecular weight	287.407
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.2
Synonyms	NCGC00162145-02 ZINC2539820 Biomol-NT_000159 D0D3PZ N,N-Dipropyl-5-carboxamidotryptamine PDSP1_001262 3-[2-(dipropylamino)ethyl]-1H-indole-5-carboxamide CAS_156314 DP5CT NCGC00015310-01 PDSP2_001599 AC1L4FYC Lopac-D-132 NCGC00015310-04 NN-DIPROP-5-CT BPBio1_000662 N,N-Dipropyl-5-carboxamidotryptamine maleate PDSP1_001615 74885-25-9 CCG-204501 GTPL122 NCGC00015310-02 SCHEMBL8891095 BDBM81789 CHEMBL1332062 Lopac0_000408 NCGC00162145-01 NSC_156314 1H-Indole-5-carboxamide, 3-(2-(dipropylamino)ethyl)- BRD-K32645441-001-01-4 DP-5-CT N,N-Dipropylcarboxamidotryptamine PDSP2_001246 CHEBI:92566 L000940 NCGC00015310-03 [ Show all ]
Inchi Key	DPXOFRGRKPFZOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)
PubChem CID	156314
ChEMBL	CHEMBL1332062
IUPHAR	122
BindingDB	81789
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.37 nM	PMID7647964	PDSP,BindingDB
Ki	13.48 nM	PMID7647964	PDSP,BindingDB

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