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| Name | Prostaglandin F2-alpha receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | PTGFR |
| Synonym | Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor [ Show all ] |
| Disease | Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease [ Show all ] |
| Length | 359 |
| Amino acid sequence | MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST |
| UniProt | P43088 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P43088 |
| 3D structure model | This predicted structure model is from GPCR-EXP P43088. |
| BioLiP | N/A |
| Therapeutic Target Database | T75797 |
| ChEMBL | CHEMBL1987 |
| IUPHAR | 344 |
| DrugBank | BE0000610 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 1593 |  CHEMBL207203 | C23H24ClNO5S | 461.957 | 5 / 2 | 3.0 | Yes |
| 1826 |  CHEMBL314533 | C38H34N2O4S | 614.76 | 4 / 1 | 7.6 | No |
| 4553 |  CHEMBL430124 | C20H27NO4S | 377.499 | 5 / 2 | 2.4 | Yes |
| 521597 |  CHEMBL3793009 | C20H22ClNO6 | 407.847 | 7 / 2 | 3.2 | Yes |
| 536084 |  CHEMBL354419 | C20H18N6O2 | 374.404 | 7 / 1 | 1.8 | Yes |
| 6566 |  CHEMBL479439 | C25H21Cl2F3N2O4S | 573.408 | 7 / 1 | 4.8 | No |
| 10069 |  2,2-Dimethyl-3-(nitrooxy)propanoic acid | C5H9NO5 | 163.129 | 5 / 1 | 0.9 | Yes |
| 10638 |  BDBM85718 | C20H34N4O3 | 378.517 | 6 / 4 | 2.8 | Yes |
| 11632 |  AH 6809 | C17H14O5 | 298.294 | 5 / 1 | 3.9 | Yes |
| 11958 |  Bimatoprost | C25H37NO4 | 415.574 | 4 / 4 | 2.8 | Yes |
| 12708 |  CHEMBL323591 | C23H31ClO6 | 438.945 | 6 / 4 | 3.0 | Yes |
| 12709 |  CHEMBL428794 | C23H31ClO6 | 438.945 | 6 / 4 | 3.0 | Yes |
| 12774 |  CID 53394056 | C22H30O5 | 374.477 | 5 / 3 | 2.1 | Yes |
| 13136 |  CHEMBL275245 | C23H33NO5 | 403.519 | 5 / 2 | 2.2 | Yes |
| 442248 |  [(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-Trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acid | C19H35O5P | 374.458 | 5 / 4 | 1.9 | Yes |
| 16335 |  CHEMBL90491 | C37H32N2O4S | 600.733 | 4 / 1 | 7.3 | No |
| 536545 |  CHEMBL3896035 | C27H36F4N4O5S | 604.662 | 11 / 2 | 5.6 | No |
| 22802 |  CHEMBL601299 | C20H14Cl3NO3S | 454.746 | 4 / 2 | 6.4 | No |
| 553381 |  prostaglandin D2 | C20H32O5 | 352.471 | 5 / 3 | 2.6 | Yes |
| 536643 |  SCHEMBL671511 | C29H38F4N4O5S | 630.7 | 11 / 2 | 6.2 | No |
| 553390 |  Sepetaprost | C26H36F2O6 | 482.565 | 8 / 2 | 3.8 | Yes |
| 28506 |  CHEMBL1080281 | C24H15Cl2F3N4O3S | 567.364 | 9 / 1 | 5.9 | No |
| 522426 |  CHEMBL3793911 | C23H28N2O4 | 396.487 | 5 / 1 | 1.1 | Yes |
| 522429 |  CHEMBL3794185 | C21H23ClO5S | 422.92 | 6 / 2 | 4.4 | Yes |
| 30385 |  CHEMBL433752 | C22H29ClO6 | 424.918 | 6 / 3 | 3.1 | Yes |
| 30387 |  CHEMBL183193 | C22H29ClO6 | 424.918 | 6 / 3 | 3.1 | Yes |
| 31003 |  CHEMBL208260 | C21H18ClF2NO2 | 389.827 | 4 / 1 | 4.9 | Yes |
| 32683 |  CHEMBL36911 | C23H35FO5 | 410.526 | 6 / 4 | 4.0 | Yes |
| 34820 |  UNII-86KF5VSV88 | C27H21F3N2O3 | 478.471 | 6 / 2 | 5.1 | No |
| 35380 |  CHEMBL363533 | C23H31N3O5S | 461.577 | 7 / 2 | 2.8 | Yes |
| 37746 |  CHEMBL240436 | C24H25ClN2O3S | 456.985 | 4 / 1 | 5.3 | No |
| 38275 |  CHEMBL428524 | C19H35NO4 | 341.492 | 4 / 2 | 3.4 | Yes |
| 38283 |  CHEMBL14286 | C19H35NO4 | 341.492 | 4 / 2 | 3.4 | Yes |
| 38292 |  64054-40-6 | C19H35NO4 | 341.492 | 4 / 2 | 3.4 | Yes |
| 38596 |  CHEMBL425681 | C22H34O6 | 394.508 | 6 / 4 | 3.2 | Yes |
| 41883 |  CHEMBL173299 | C22H34O5S | 410.569 | 6 / 4 | 3.8 | Yes |
| 44512 |  CHEMBL599051 | C21H18ClNO3S | 399.889 | 4 / 2 | 4.9 | Yes |
| 45153 |  CHEMBL289660 | C24H35F3O5 | 460.534 | 8 / 4 | 4.8 | Yes |
| 45457 |  CHEMBL287080 | C24H31F3O5 | 456.502 | 8 / 4 | 3.6 | Yes |
| 46925 |  CHEMBL336543 | C19H35O6P | 390.457 | 6 / 5 | 1.4 | Yes |
| 47918 |  SC-51322 | C22H20ClN3O4S | 457.929 | 5 / 2 | 3.5 | Yes |
| 49873 |  CHEMBL14600 | C19H25N5O2S | 387.502 | 6 / 2 | 2.2 | Yes |
| 537315 |  CHEMBL3956817 | C22H30O6 | 390.476 | 6 / 3 | 2.3 | Yes |
| 537318 |  CHEMBL3920347 | C22H30O6 | 390.476 | 6 / 3 | 2.3 | Yes |
| 55256 |  CHEMBL35715 | C24H38O6 | 422.562 | 6 / 4 | 3.9 | Yes |
| 56459 |  CHEMBL489310 | C24H16Cl2F2N2O4S | 537.359 | 6 / 1 | 5.8 | No |
| 56850 |  CHEMBL125588 | C27H22O3S | 426.53 | 4 / 1 | 6.1 | No |
| 60363 |  CHEMBL461571 | C27H21ClF3NO5 | 531.912 | 8 / 1 | 7.1 | No |
| 63132 |  CHEMBL605330 | C24H22F3NO3S | 461.499 | 7 / 2 | 5.9 | No |
| 65311 |  CHEMBL603690 | C24H22F3NO3S | 461.499 | 7 / 2 | 5.9 | No |
| 65574 |  FR-181157 | C30H26NNaO4 | 487.531 | 5 / 0 | N/A | N/A |
| 67993 |  CHEMBL39784 | C24H35F3O5 | 460.534 | 8 / 4 | 4.8 | Yes |
| 69819 |  CHEMBL280223 | C23H31NO4 | 385.504 | 4 / 2 | 2.8 | Yes |
| 72059 |  CHEMBL1910332 | C39H42N6O6 | 690.801 | 7 / 4 | 4.0 | No |
| 73314 |  CHEMBL599262 | C23H22ClNO3S | 427.943 | 4 / 2 | 5.7 | No |
| 73630 |  16-phenoxy tetranor Prostaglandin F2alpha | C22H30O6 | 390.476 | 6 / 4 | 2.1 | Yes |
| 74338 |  CHEMBL1093125 | C28H19F3N2O5S | 552.524 | 8 / 2 | 4.3 | No |
| 76720 |  CHEMBL133910 | C23H43O5P | 430.566 | 5 / 4 | 3.1 | Yes |
| 77036 |  CHEMBL603462 | C25H22F3NO3S | 473.51 | 7 / 2 | 5.9 | No |
| 78743 |  CHEMBL88275 | C25H36O5 | 416.558 | 5 / 4 | 3.6 | Yes |
| 78745 |  CHEMBL2114230 | C25H36O5 | 416.558 | 5 / 4 | 3.6 | Yes |
| 79883 |  MF310 | C35H31F6N3O8S | 767.696 | 15 / 1 | 5.9 | No |
| 80790 |  CHEMBL1079732 | C22H13Cl4FN4O3S2 | 606.289 | 8 / 1 | 7.7 | No |
| 82010 |  CHEMBL598198 | C25H22F3N5OS | 497.54 | 8 / 2 | 5.5 | No |
| 83061 |  CHEMBL173811 | C19H31NO5S2 | 417.579 | 8 / 4 | 3.1 | Yes |
| 83790 |  Prostaglandin F2I+/- isopropyl ester | C23H40O5 | 396.568 | 5 / 3 | 3.8 | Yes |
| 85015 |  UNII-V02XH3498Z | C36H32N2O4S | 588.722 | 5 / 1 | 7.5 | No |
| 538144 |  CHEMBL3805134 | C22H30O6 | 390.476 | 6 / 3 | 2.3 | Yes |
| 538146 |  CHEMBL3982726 | C22H30O6 | 390.476 | 6 / 3 | 2.3 | Yes |
| 91071 |  CHEMBL1081902 | C23H14Cl2F3N3O3S2 | 572.398 | 9 / 1 | 6.8 | No |
| 94023 |  CHEMBL280442 | C22H31NO4 | 373.493 | 4 / 2 | 2.9 | Yes |
| 94049 |  CHEMBL563480 | C19H16Cl2N4O2S | 435.323 | 6 / 1 | 4.7 | Yes |
| 538342 |  CHEMBL3904644 | C24H32O6 | 416.514 | 6 / 3 | 2.4 | Yes |
| 96122 |  latanoprost | C26H40O5 | 432.601 | 5 / 3 | 4.3 | Yes |
| 96127 |  CHEMBL364375 | C26H40O5 | 432.601 | 5 / 3 | 4.3 | Yes |
| 96133 |  15(S)-Latanoprost | C26H40O5 | 432.601 | 5 / 3 | 4.3 | Yes |
| 524352 |  CHEMBL3798917 | C24H31ClN2O7 | 494.969 | 8 / 3 | N/A | N/A |
| 524393 |  CHEMBL3805176 | C22H25NO5S | 415.504 | 7 / 2 | 3.6 | Yes |
| 98614 |  BDBM85715 | C21H37NO6S | 431.588 | 6 / 4 | 2.0 | Yes |
| 553743 |  UNII-1GY0F1HMVT | C21H27ClO6 | 410.891 | 6 / 3 | 2.6 | Yes |
| 103681 |  CHEMBL1083400 | C26H20ClF3N2O3 | 500.902 | 6 / 2 | 5.8 | No |
| 553761 |  L-888607 | C19H15ClFNO2S | 375.842 | 4 / 1 | 4.4 | Yes |
| 104738 |  CHEMBL165010 | C17H16O2S | 284.373 | 3 / 1 | 4.3 | Yes |
| 104862 |  CHEMBL557109 | C16H19N3O3S | 333.406 | 6 / 1 | 3.1 | Yes |
| 108161 |  CHEMBL14439 | C21H29NO4S | 391.526 | 5 / 2 | 2.3 | Yes |
| 524698 |  CHEMBL3793892 | C20H22ClNO5S | 423.908 | 7 / 2 | 3.8 | Yes |
| 524704 |  CHEMBL3793515 | C20H22ClNO5S | 423.908 | 7 / 2 | 3.8 | Yes |
| 110736 |  CHEMBL482018 | C25H21Cl2F3N2O4S | 573.408 | 7 / 1 | 4.8 | No |
| 111506 |  UNII-U73BV4MML7 | C22H19ClNNaO3 | 403.838 | 4 / 0 | N/A | N/A |
| 115475 |  BDBM85721 | C20H37NO3 | 339.52 | 4 / 4 | 2.6 | Yes |
| 115554 |  CHEMBL1910325 | C35H39N5O6 | 625.726 | 7 / 4 | 2.9 | No |
| 115628 |  ILOPROST | C22H32O4 | 360.494 | 4 / 3 | 2.8 | Yes |
| 553853 |  ILOPROST | C22H32O4 | 360.494 | 4 / 3 | 2.8 | Yes |
| 115654 |  ILOPROST | C22H32O4 | 360.494 | 4 / 3 | 2.8 | Yes |
| 116622 |  CHEMBL467114 | C20H13Cl2FNO3- | 405.226 | 5 / 0 | 6.1 | No |
| 118204 |  CHEMBL563949 | C16H12F2N2O4S | 366.339 | 7 / 1 | 2.6 | Yes |
| 553875 |  Latanoprost acid | C23H34O5 | 390.52 | 5 / 4 | 3.1 | Yes |
| 549337 |  CHEMBL3889508 | C23H33NO7S | 467.577 | 7 / 4 | 1.4 | Yes |
| 121268 |  CHEMBL1084552 | C26H20ClF3N2O4 | 516.901 | 7 / 2 | 6.1 | No |
| 121860 |  CHEMBL479664 | C25H22F4N2O4S | 522.515 | 8 / 1 | 3.7 | No |
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