Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	AH 6809
Molecular formula	C17H14O5
IUPAC name	9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid
Molecular weight	298.294
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.9
Synonyms	6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid AC1L3OV2 AQFFXPQJLZFABJ-UHFFFAOYSA-N CS-1549 J-019193 PDSP1_001548 ZINC3995668 6-Isopropoxy-9-xanthone-2-carboxylic acid C17H14O5 DTXSID80187106 L000101 SR-01000597664 33458-93-4 9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo- AH6809, >=98%, crystalline solid or supercooled liquid HMS3648F13 NCGC00024721-01 Tocris-0671 6-isopropoxy-9-oxo-9h-xanthene-2-carboxylic acid AC1Q5UST BDBM85184 CTK1C3251 KB-74545 PDSP2_001532 AH-6809 CAS_33458-93-4 GTPL1896 LS-174420 SR-01000597664-1 3425AH 9H-Xanthene-2-carboxylicacid, 6-(1-methylethoxy)-9-oxo- AKOS024458601 CHEMBL1317823 HY-10418 NSC_119461 W-5361 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid ACM33458934 BRD-K59339270-001-01-8 D0J9PG KS-0000180F SCHEMBL1163801 9-oxo-6-propan-2-yloxyxanthene-2-carboxylic acid AH6809 CHEBI:95289 HMS3266H17 MolPort-009-018-350 SR-01000597664-2 [ Show all ]
Inchi Key	AQFFXPQJLZFABJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
PubChem CID	119461
ChEMBL	CHEMBL1317823
IUPHAR	1896
BindingDB	85184
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID10634944	PDSP,BindingDB

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417