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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL364375
Molecular formula	C26H40O5
IUPAC name	propan-2-yl (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Molecular weight	432.601
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	4.3
Synonyms	J-502634 PhXA34 Xalatan Fixed Flow Device 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-,1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R),3-alpha,5-alpha))- BC208340 LATANOPROST (PHXA41) SCHEMBL1649402 (E)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-hept-5-enoic acid isopropyl ester 913258-34-1 CHEBI:94503 isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate MolPort-005-935-069 trans-Latanoprost 2077AH AKOS016002154 latanaprost propan-2-yl (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Z-3157 5-trans-Latanoprost BDBM50150899 Latanoprost [USAN:INN:BAN] TC-147663 (Z)-isopropyl 7-((1R,2R)-3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate AC1NQZZ7 Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate PDSP2_001702 XA 41 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R),3-alpha,5-alpha))- API0003129 latanoprost (isopropyl ester) SCHEMBL1286379 ZINC4097345 C26H40O5 LS-74633 trans Latanoprost 13,14-dihydro-15(R)-17-phenyl-18,19,20-trinor-prostaglandin-2-alpha-isopropyl ester AJ-47997 [ Show all ]
Inchi Key	GGXICVAJURFBLW-RDSJPUOVSA-N
Inchi ID	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3+/t21-,22+,23+,24-,25+/m0/s1
PubChem CID	5282380
ChEMBL	CHEMBL364375
IUPHAR	N/A
BindingDB	50150899
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
96128	Prostacyclin receptor	P43119	PTGIR	Homo sapiens (Human)	386
460077	Prostaglandin E2 receptor EP1 subtype	P34995	PTGER1	Homo sapiens (Human)	402
96129	Prostaglandin E2 receptor EP2 subtype	P43116	PTGER2	Homo sapiens (Human)	358
460075	Prostaglandin E2 receptor EP3 subtype	P43115	PTGER3	Homo sapiens (Human)	390
460076	Prostaglandin E2 receptor EP4 subtype	P35408	PTGER4	Homo sapiens (Human)	488
96127	Prostaglandin F2-alpha receptor	P43088	PTGFR	Homo sapiens (Human)	359
96130	Prostaglandin F2-alpha receptor	P37289	PTGFR	Bos taurus (Bovine)	362

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