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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	CHEMBL364375
Molecular formula	C26H40O5
IUPAC name	propan-2-yl (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Molecular weight	432.601
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	4.3
Synonyms	J-502634 PhXA34 Xalatan Fixed Flow Device 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-,1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R),3-alpha,5-alpha))- BC208340 LATANOPROST (PHXA41) SCHEMBL1649402 (E)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-hept-5-enoic acid isopropyl ester 913258-34-1 CHEBI:94503 isopropyl (E)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate MolPort-005-935-069 trans-Latanoprost 2077AH AKOS016002154 latanaprost propan-2-yl (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Z-3157 5-trans-Latanoprost BDBM50150899 Latanoprost [USAN:INN:BAN] TC-147663 (Z)-isopropyl 7-((1R,2R)-3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate AC1NQZZ7 Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate PDSP2_001702 XA 41 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R),3-alpha,5-alpha))- API0003129 latanoprost (isopropyl ester) SCHEMBL1286379 ZINC4097345 C26H40O5 LS-74633 trans Latanoprost 13,14-dihydro-15(R)-17-phenyl-18,19,20-trinor-prostaglandin-2-alpha-isopropyl ester AJ-47997 [ Show all ]
Inchi Key	GGXICVAJURFBLW-RDSJPUOVSA-N
Inchi ID	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3+/t21-,22+,23+,24-,25+/m0/s1
PubChem CID	5282380
ChEMBL	CHEMBL364375
IUPHAR	N/A
BindingDB	50150899
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	34.4 nM	PMID15357985	BindingDB,ChEMBL
Ki	555.0 nM	PMID10634944	BindingDB
Response	75.0 %	PMID15357985	ChEMBL

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