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| Name | Prostaglandin E2 receptor EP3 subtype |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | PTGER3 |
| Synonym | EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 [ Show all ] |
| Disease | Pain Peripheral vascular disease Asthma Glaucoma |
| Length | 390 |
| Amino acid sequence | MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER |
| UniProt | P43115 |
| Protein Data Bank | 6m9t |
| GPCR-HGmod model | P43115 |
| 3D structure model | This structure is from PDB ID 6m9t. |
| BioLiP | BL0434681 |
| Therapeutic Target Database | T85467 |
| ChEMBL | CHEMBL3710 |
| IUPHAR | 342 |
| DrugBank | BE0002375 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 428 |  CHEMBL2164612 | C40H43BF4N2O4 | 702.598 | 10 / 1 | N/A | No |
| 638 |  CHEMBL1093559 | C28H17F5N2O4S | 572.506 | 9 / 1 | 5.6 | No |
| 853 |  CHEMBL180742 | C26H22Cl2O4 | 469.358 | 4 / 2 | 6.4 | No |
| 535935 |  CHEMBL3904946 | C24H25FO4 | 396.458 | 5 / 2 | 3.9 | Yes |
| 1591 |  CHEMBL207203 | C23H24ClNO5S | 461.957 | 5 / 2 | 3.0 | Yes |
| 1827 |  CHEMBL314533 | C38H34N2O4S | 614.76 | 4 / 1 | 7.6 | No |
| 3052 |  CHEMBL3115074 | C23H28N2O4 | 396.487 | 5 / 2 | 1.3 | Yes |
| 4550 |  CHEMBL430124 | C20H27NO4S | 377.499 | 5 / 2 | 2.4 | Yes |
| 521600 |  CHEMBL3793009 | C20H22ClNO6 | 407.847 | 7 / 2 | 3.2 | Yes |
| 4905 |  CHEMBL518110 | C20H14Cl2N2O4S3 | 513.422 | 6 / 2 | 6.2 | No |
| 557441 |  CHEMBL354419 | C20H18N6O2 | 374.404 | 7 / 1 | 1.8 | Yes |
| 6135 |  CHEMBL481614 | C25H22Cl2F2N2O4S | 555.418 | 6 / 1 | 4.7 | No |
| 6209 |  CHEMBL522435 | C26H17F3N4O4S | 538.501 | 9 / 1 | 4.3 | No |
| 6565 |  CHEMBL479439 | C25H21Cl2F3N2O4S | 573.408 | 7 / 1 | 4.8 | No |
| 6656 |  CHEMBL313266 | C27H27NO4S4 | 557.756 | 7 / 1 | 6.5 | No |
| 7163 |  CHEMBL1272085 | C21H19ClFN3O2 | 399.85 | 3 / 2 | 4.2 | Yes |
| 8000 |  CHEMBL428370 | C25H20BrClO3 | 483.786 | 3 / 1 | 6.6 | No |
| 8167 |  CHEMBL1271637 | C19H15Cl2N3O2 | 388.248 | 2 / 2 | 3.9 | Yes |
| 8243 |  CHEMBL517282 | C28H20F2N2O4S | 518.535 | 6 / 1 | 5.8 | No |
| 8447 |  CHEMBL417171 | C21H26F3NO4 | 413.437 | 7 / 2 | 3.1 | Yes |
| 9200 |  CHEMBL123844 | C27H22O3 | 394.47 | 3 / 1 | 5.3 | No |
| 536222 |  SCHEMBL5205658 | C27H39ClO4 | 463.055 | 4 / 2 | 5.5 | No |
| 9677 |  CHEMBL464270 | C22H18Cl2N2O6S3 | 573.474 | 8 / 2 | 6.1 | No |
| 10347 |  CID 52944193 | C52H48O6 | 768.95 | 6 / 2 | N/A | No |
| 11429 |  CHEMBL383515 | C24H28ClNO4 | 429.941 | 4 / 2 | 4.4 | Yes |
| 11542 |  CHEMBL1770321 | C24H16N2O4 | 396.402 | 4 / 2 | 3.9 | Yes |
| 11636 |  AH 6809 | C17H14O5 | 298.294 | 5 / 1 | 3.9 | Yes |
| 11960 |  Bimatoprost | C25H37NO4 | 415.574 | 4 / 4 | 2.8 | Yes |
| 12366 |  BDBM50370468 | C25H22O4 | 386.447 | 4 / 2 | 5.5 | No |
| 553321 |  Cicaprost | C22H30O5 | 374.477 | 5 / 3 | 2.1 | Yes |
| 12778 |  CID 53394056 | C22H30O5 | 374.477 | 5 / 3 | 2.1 | Yes |
| 12886 |  Thiophene-2-boronic acid | C4H5BO2S | 127.952 | 3 / 2 | N/A | N/A |
| 521842 |  CHEMBL3798145 | C14H13N5OS | 299.352 | 5 / 1 | 1.8 | Yes |
| 13138 |  CHEMBL275245 | C23H33NO5 | 403.519 | 5 / 2 | 2.2 | Yes |
| 13564 |  CHEMBL125110 | C26H22O3S | 414.519 | 4 / 1 | 6.1 | No |
| 464547 |  CHEMBL3586353 | C23H19ClN2OS | 406.928 | 4 / 0 | 5.2 | No |
| 13898 |  CHEMBL181035 | C24H20O3 | 356.421 | 3 / 1 | 5.6 | No |
| 13968 |  CHEMBL549909 | C21H21N3O3S | 395.477 | 6 / 1 | 4.4 | Yes |
| 14338 |  CHEMBL482155 | C23H22Cl2N2O4S2 | 525.459 | 5 / 1 | 4.5 | No |
| 14341 |  CHEMBL251294 | C20H27NO4 | 345.439 | 4 / 2 | 2.8 | Yes |
| 442244 |  [(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-Trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acid | C19H35O5P | 374.458 | 5 / 4 | 1.9 | Yes |
| 15307 |  CHEMBL180089 | C26H23FO3 | 402.465 | 4 / 1 | 6.4 | No |
| 15658 |  CHEMBL265086 | C26H24O5S | 448.533 | 5 / 1 | 4.5 | Yes |
| 16334 |  CHEMBL90491 | C37H32N2O4S | 600.733 | 4 / 1 | 7.3 | No |
| 17051 |  CHEMBL87797 | C28H28N2O5S2 | 536.661 | 6 / 2 | 6.0 | No |
| 459367 |  SCHEMBL2195516 | C23H38O5 | 394.552 | 5 / 2 | 4.1 | Yes |
| 459372 |  SCHEMBL2191405 | C27H34O5S | 470.624 | 6 / 2 | 4.4 | Yes |
| 536456 |  SCHEMBL1310801 | C21H25NO5 | 371.433 | 5 / 1 | 3.4 | Yes |
| 18906 |  CHEMBL557312 | C18H15N3O3S | 353.396 | 6 / 1 | 3.3 | Yes |
| 19596 |  CHEMBL490692 | C28H21ClN2O4S | 516.996 | 4 / 1 | 6.2 | No |
| 19835 |  208516-15-8 | C10H16BNO4S | 257.111 | 5 / 3 | N/A | N/A |
| 20029 |  CHEMBL382197 | C28H31NO4S | 477.619 | 5 / 2 | 5.4 | No |
| 536484 |  SCHEMBL2011904 | C24H34O4 | 386.532 | 4 / 2 | 4.4 | Yes |
| 20679 |  CHEMBL565797 | C28H22N2O3S2 | 498.615 | 4 / 1 | 6.1 | No |
| 21816 |  CHEMBL567274 | C26H20N2O3S2 | 472.577 | 4 / 1 | 5.7 | No |
| 22144 |  DG-041 | C23H15Cl4FN2O3S2 | 592.302 | 5 / 1 | 7.8 | No |
| 536547 |  CHEMBL3896035 | C27H36F4N4O5S | 604.662 | 11 / 2 | 5.6 | No |
| 22803 |  CHEMBL601299 | C20H14Cl3NO3S | 454.746 | 4 / 2 | 6.4 | No |
| 23034 |  CHEMBL46395 | C22H30F3NO4 | 429.48 | 7 / 2 | 3.9 | Yes |
| 23670 |  CHEMBL388655 | C25H20ClFO3 | 422.88 | 4 / 1 | 6.0 | No |
| 459418 |  SCHEMBL2194130 | C24H32O5 | 400.515 | 5 / 3 | 3.0 | Yes |
| 23778 |  CHEMBL207577 | C25H21ClO3 | 404.89 | 3 / 1 | 5.9 | No |
| 24186 |  CHEMBL464042 | C22H17Cl2N3O7S3 | 602.472 | 8 / 3 | 3.7 | No |
| 465996 |  CHEMBL3586309 | C24H22N2O2S | 402.512 | 5 / 0 | 4.5 | Yes |
| 25008 |  CHEMBL489315 | C25H19F3N2O5S | 516.491 | 8 / 1 | 4.6 | No |
| 536647 |  SCHEMBL671511 | C29H38F4N4O5S | 630.7 | 11 / 2 | 6.2 | No |
| 536661 |  SCHEMBL2014800 | C25H32O4S | 428.587 | 5 / 2 | 5.5 | No |
| 536674 |  SCHEMBL1309617 | C21H25NO4S | 387.494 | 5 / 1 | 4.0 | Yes |
| 26879 |  CHEMBL463815 | C28H20Cl2N2O4S | 551.438 | 4 / 1 | 6.9 | No |
| 27375 |  CHEMBL565988 | C24H22N2O3S2 | 450.571 | 4 / 1 | 5.2 | No |
| 27526 |  CHEMBL165671 | C15H17BO2S | 272.169 | 3 / 2 | N/A | N/A |
| 27565 |  CID 52945421 | C50H44O6 | 740.896 | 6 / 2 | N/A | No |
| 27586 |  CHEMBL465297 | C26H19ClN2O6S2 | 555.016 | 6 / 2 | 5.2 | No |
| 28503 |  CHEMBL1080281 | C24H15Cl2F3N4O3S | 567.364 | 9 / 1 | 5.9 | No |
| 28687 |  CHEMBL45008 | C22H28F3NO4 | 427.464 | 7 / 2 | 3.4 | Yes |
| 28692 |  CHEMBL440474 | C22H28F3NO4 | 427.464 | 7 / 2 | 3.4 | Yes |
| 522425 |  CHEMBL3793911 | C23H28N2O4 | 396.487 | 5 / 1 | 1.1 | Yes |
| 522432 |  CHEMBL3794185 | C21H23ClO5S | 422.92 | 6 / 2 | 4.4 | Yes |
| 29953 |  CHEMBL520290 | C24H18N2O4S3 | 494.598 | 6 / 2 | 5.8 | No |
| 31008 |  CHEMBL208260 | C21H18ClF2NO2 | 389.827 | 4 / 1 | 4.9 | Yes |
| 32542 |  CHEMBL223744 | C22H31NO4 | 373.493 | 4 / 2 | 3.8 | Yes |
| 32685 |  CHEMBL36911 | C23H35FO5 | 410.526 | 6 / 4 | 4.0 | Yes |
| 32844 |  CHEMBL560868 | C21H20N4O3S | 408.476 | 6 / 1 | 3.0 | Yes |
| 32856 |  CHEMBL291182 | C21H28F3NO4 | 415.453 | 7 / 2 | 3.4 | Yes |
| 33066 |  memantine | C12H21N | 179.307 | 1 / 1 | 3.3 | Yes |
| 33168 |  CHEMBL474948 | C24H16ClF3N2O4S | 520.907 | 7 / 1 | 5.3 | No |
| 467012 |  CHEMBL3589082 | C20H21FN4O2 | 368.412 | 4 / 2 | 2.0 | Yes |
| 33330 |  CHEMBL481984 | C16H12Cl2N6O4S3 | 519.39 | 9 / 2 | 4.1 | No |
| 34373 |  CHEMBL434247 | C29H26O3 | 422.524 | 3 / 1 | 7.0 | No |
| 34503 |  CHEMBL1770331 | C20H15NO4 | 333.343 | 4 / 2 | 3.9 | Yes |
| 34828 |  UNII-86KF5VSV88 | C27H21F3N2O3 | 478.471 | 6 / 2 | 5.1 | No |
| 35189 |  CHEMBL564190 | C20H19N3O3S | 381.45 | 6 / 1 | 4.0 | Yes |
| 35676 |  CHEMBL2204337 | C23H17NO3S3 | 451.573 | 5 / 1 | 6.1 | No |
| 36123 |  CHEMBL517180 | C26H18F2N2O6S2 | 556.555 | 8 / 2 | 4.7 | No |
| 36599 |  CHEMBL1091893 | C22H14Cl4N2O4S2 | 576.284 | 5 / 1 | 6.1 | No |
| 36927 |  CHEMBL482380 | C26H19ClN2O4S2 | 523.018 | 5 / 2 | 6.4 | No |
| 37721 |  CHEMBL480012 | C20H13Cl3N2O4S3 | 547.864 | 6 / 2 | 6.8 | No |
| 37747 |  CHEMBL240436 | C24H25ClN2O3S | 456.985 | 4 / 1 | 5.3 | No |
| 37926 |  CHEMBL480808 | C16H11Cl2N5O6S3 | 536.373 | 9 / 3 | 3.3 | No |
| 38278 |  CHEMBL428524 | C19H35NO4 | 341.492 | 4 / 2 | 3.4 | Yes |
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