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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	CHEMBL1091893
Molecular formula	C22H14Cl4N2O4S2
IUPAC name	(E)-3-[1-[(2,4-dichlorophenyl)methyl]-2-oxo-3H-indol-7-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamide
Molecular weight	576.284
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	6.1
Synonyms	BDBM50315490 3-(1-(2,4-dichlorobenzyl)-2-oxoindolin-7-yl)-N-(4,5-dichlorothiophen-2-ylsulfonyl)acrylamide
Inchi Key	BZMUHPHCPVKBAC-FNORWQNLSA-N
Inchi ID	InChI=1S/C22H14Cl4N2O4S2/c23-15-6-4-14(16(24)9-15)11-28-19(30)8-13-3-1-2-12(21(13)28)5-7-18(29)27-34(31,32)20-10-17(25)22(26)33-20/h1-7,9-10H,8,11H2,(H,27,29)/b7-5+
PubChem CID	46885341
ChEMBL	CHEMBL1091893
IUPHAR	N/A
BindingDB	50315490
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2.9 nM	PMID20303752	BindingDB,ChEMBL
IC50	92.8 nM	PMID20303752	BindingDB,ChEMBL

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