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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	CHEMBL522435
Molecular formula	C26H17F3N4O4S
IUPAC name	(E)-3-(1-methyl-4-quinoxalin-2-yloxyindol-3-yl)-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
Molecular weight	538.501
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	4.3
Synonyms	BDBM50248448 3-(1-methyl-4-(quinoxalin-2-yloxy)-1H-indol-3-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide
Inchi Key	AIHBNUULUGTKAA-MDZDMXLPSA-N
Inchi ID	InChI=1S/C26H17F3N4O4S/c1-33-14-15(9-10-24(34)32-38(35,36)23-12-17(28)16(27)11-18(23)29)26-21(33)7-4-8-22(26)37-25-13-30-19-5-2-3-6-20(19)31-25/h2-14H,1H3,(H,32,34)/b10-9+
PubChem CID	44565044
ChEMBL	CHEMBL522435
IUPHAR	N/A
BindingDB	50248448
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.2 nM	PMID19188065	BindingDB,ChEMBL
IC50	128.2 nM	PMID19188065	BindingDB,ChEMBL
Ratio IC50	17.7 -	PMID19188065	ChEMBL

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