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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	Thiophene-2-boronic acid
Molecular formula	C4H5BO2S
IUPAC name	thiophen-2-ylboronic acid
Molecular weight	127.952
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	None
Synonyms	C-1156 DTXSID60370059 J-400313 2-Boronothiophene PubChem6435 2-thiophen-boronic acid STK503714 2-thiophenyl boronic acid thiophen-2-ylboranediol 65080-EP2270011A1 thiophenylboronic acid AC-788 ALBB-006112 BBL104405 CM13586 FS000329 LS00104 2-thienyl-boronic-acid RTR-021227 2-thiophene boronic acid Thienylboronic acid 25832-EP2289965A1 65080-EP2298767A1 TRA0054314 ACMC-209mv5 AN-15509 BCP26856 CTK2F2821 I09-0338 (thiophen-2-yl)boronic acid NCGC00249453-01 2-thiopeneboronic acid SCHEMBL38298 2-Thiopheneboronic acid, 97% thiophen-2-yl-2-boronic acid 2thiopheneboronic acid thiopheneboronic acid AB04002 ZINC169743204 AK-46314 AS-3012 Boronicacid, B-2-thienyl- EN300-49146 KB-61671 2-thienyl boronic acid RL04332 2-thiophenboronic acid SY002974 2-thipheneboronic acid thiophen-2-ylboronic acid 65080-EP2281815A1 TL8003920 AC1MC01W AM804138 BC000758 CS-W000053 FT-0082516 MFCD00151850 2-Thienylboronic acid SBB004243 2-thiophene-boronic acid thiophen-2-boronic acid 25832-EP2305769A2 Thiophene-2-boronicacid 65080-EP2308812A2 VB10390 ACN-S003910 ANW-33903 BDBM50067899 BR-46314 DB-028205 InChI=1/C4H5BO2S/c6-5(7)4-2-1-3-8-4/h1-3,6-7 165T680 PubChem1883 2-thiophen boronic acid ST2411237 2-Thiopheneboronicacid thiophen-2-yl-boronic acid 6165-68-0 thiophenyl 2-boronic acid AB1001875 AKOS000265495 AS06041 CHEMBL141272 F9995-0586 KSC352Q2D 2-thienyl-boronic acid RP00865 2-thiophene boric acid thien-2-ylboronic acid 25832-EP2272822A1 thiophene 2-boronic acid 65080-EP2287141A1 TR-021227 AC1Q716G AMTB949 BC210702 CT-209 FT-0601795 MolPort-000-142-467 2-Thienylboronic acid, >=95.0% SC-05775 2-Thiopheneboronic acid thiophen-2-yl boronic acid 25832-EP2315303A1 thiophene2-boronic acid AB0007023 Z1741960669 ACT02304 ARYHTUPFQTUBBG-UHFFFAOYSA-N Boronic acid, thienyl- [ Show all ]
Inchi Key	ARYHTUPFQTUBBG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H5BO2S/c6-5(7)4-2-1-3-8-4/h1-3,6-7H
PubChem CID	2733960
ChEMBL	CHEMBL141272
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Residual binding	74.0 %	PMID11266183	ChEMBL

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