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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	CHEMBL520290
Molecular formula	C24H18N2O4S3
IUPAC name	2-[(3-naphthalen-2-ylsulfanyl-1H-indol-4-yl)oxy]-N-thiophen-2-ylsulfonylacetamide
Molecular weight	494.598
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.8
Synonyms	BDBM50254642 2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(thiophen-2-ylsulfonyl)acetamide
Inchi Key	BPWBFGBNTRGBLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H18N2O4S3/c27-22(26-33(28,29)23-9-4-12-31-23)15-30-20-8-3-7-19-24(20)21(14-25-19)32-18-11-10-16-5-1-2-6-17(16)13-18/h1-14,25H,15H2,(H,26,27)
PubChem CID	44570149
ChEMBL	CHEMBL520290
IUPHAR	N/A
BindingDB	50254642
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.0 nM	PMID19022669	BindingDB,ChEMBL
IC50	27.5 nM	PMID19022669	BindingDB,ChEMBL

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