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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	2,2-Dimethyl-3-(nitrooxy)propanoic acid
Molecular formula	C5H9NO5
IUPAC name	2,2-dimethyl-3-nitrooxypropanoic acid
Molecular weight	163.129
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.9
Synonyms	4CH-010890 DS-2170 SCHEMBL2015730 ANW-54102 KB-224871 Z4072 2,2-dimethyl-3-(nitrooxy) propanoic acid CHEMBL361225 MolPort-023-329-988 AB0051039 DTXSID80437971 ST24021445 AX8218254 KS-000024O1 ZINC28358176 CTK8B6708 Propanoic acid, 2,2-dimethyl-3-(nitrooxy)- AKOS016001376 FCH1562731 TC-142847 130432-36-9 M-9672 [ Show all ]
Inchi Key	AOADQMBSEJVBHG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H9NO5/c1-5(2,4(7)8)3-11-6(9)10/h3H2,1-2H3,(H,7,8)
PubChem CID	10313259
ChEMBL	CHEMBL361225
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	4.69 -	PMID15341967	ChEMBL

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