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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	CHEMBL363533
Molecular formula	C23H31N3O5S
IUPAC name	(2S)-2-acetamido-N-(2-hydroxy-3-naphthalen-1-yloxypropyl)-3-methyl-3-nitrososulfanyl-N-propan-2-ylbutanamide
Molecular weight	461.577
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.8
Synonyms	N/A
Inchi Key	BXSAYABAOOFXAH-ZYZRXSCRSA-N
Inchi ID	InChI=1S/C23H31N3O5S/c1-15(2)26(22(29)21(24-16(3)27)23(4,5)32-25-30)13-18(28)14-31-20-12-8-10-17-9-6-7-11-19(17)20/h6-12,15,18,21,28H,13-14H2,1-5H3,(H,24,27)/t18?,21-/m0/s1
PubChem CID	10344282
ChEMBL	CHEMBL363533
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	6.94 -	PMID15341967	ChEMBL

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