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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	CHEMBL39784
Molecular formula	C24H35F3O5
IUPAC name	7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]cyclopentyl]heptanoic acid
Molecular weight	460.534
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	4.8
Synonyms	7-[(1R)-2beta-[(3R)-3-Hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]-3alpha,5alpha-dihydroxycyclopentane-1alpha-yl]heptanoic acid MolPort-027-640-905 BDBM50090140 ZINC29327528 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1.alpha. DSVAWVBHUBDAPY-AHJNKEMKSA-N 7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(R)-3-hydroxy-5-(3-trifluoromethyl-phenyl)-pentyl]-cyclopentyl}-heptanoic acid SR-01000946455 HMS3648N07 9.alpha.,11.alpha.,15S-Trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prostan-1-oic acid SR-01000946455-1 [ Show all ]
Inchi Key	DSVAWVBHUBDAPY-AHJNKEMKSA-N
Inchi ID	InChI=1S/C24H35F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h5-7,14,18-22,28-30H,1-4,8-13,15H2,(H,31,32)/t18-,19+,20+,21-,22+/m0/s1
PubChem CID	10389527
ChEMBL	CHEMBL39784
IUPHAR	N/A
BindingDB	50090140
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	85.0 nM	PMID10915040	BindingDB,ChEMBL
IC50	8.6 nM	PMID10915040	BindingDB,ChEMBL

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