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| Name | Glucose-dependent insulinotropic receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GPR119 |
| Synonym | GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 [ Show all ] |
| Disease | Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes |
| Length | 335 |
| Amino acid sequence | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG |
| UniProt | Q8TDV5 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | Q8TDV5 |
| 3D structure model | This predicted structure model is from GPCR-EXP Q8TDV5. |
| BioLiP | N/A |
| Therapeutic Target Database | T93788 |
| ChEMBL | CHEMBL5652 |
| IUPHAR | 126 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 153 |  CHEMBL2058674 | C22H30N4O2 | 382.508 | 6 / 1 | 4.6 | Yes |
| 361 |  CHEMBL3260528 | C24H22ClN3O2 | 419.909 | 4 / 0 | 5.1 | No |
| 441711 |  CHEMBL3326687 | C22H24F2N6O6S | 538.527 | 13 / 0 | 2.4 | No |
| 535947 |  SCHEMBL2586921 | C22H23N3O2 | 361.445 | 4 / 1 | 5.0 | Yes |
| 1435 |  CHEMBL3113624 | C23H36N2O4S | 436.611 | 5 / 0 | 4.2 | Yes |
| 1751 |  CHEMBL2204975 | C24H33N5O3S | 471.62 | 8 / 0 | 2.8 | Yes |
| 2291 |  CHEMBL2204978 | C24H28F3N5O3S | 523.575 | 11 / 0 | 2.7 | No |
| 2320 |  CHEMBL3113843 | C25H31N5O4S | 497.614 | 7 / 0 | 3.2 | Yes |
| 521523 |  CHEMBL3716002 | C24H25FN2O5S | 472.531 | 7 / 0 | 3.5 | Yes |
| 3313 |  CHEMBL3112980 | C23H18Cl2N4O4S | 517.381 | 8 / 0 | 5.7 | No |
| 536005 |  SCHEMBL2583224 | C27H32N4O3 | 460.578 | 6 / 1 | 4.5 | Yes |
| 557402 |  SCHEMBL15507271 | C23H28FN3O4 | 429.492 | 6 / 0 | 3.5 | Yes |
| 536034 |  CHEMBL3963533 | C23H28FN3O4 | 429.492 | 6 / 0 | 3.5 | Yes |
| 536035 |  CHEMBL3894640 | C23H28FN3O4 | 429.492 | 6 / 0 | 3.5 | Yes |
| 557403 |  SCHEMBL15507270 | C23H28FN3O4 | 429.492 | 6 / 0 | 3.5 | Yes |
| 4201 |  CHEMBL2010830 | C24H29F3N2O3S | 482.562 | 7 / 0 | 3.9 | Yes |
| 4714 |  CHEMBL3113839 | C23H29N3O5S | 459.561 | 7 / 0 | 3.4 | Yes |
| 536066 |  SCHEMBL2582970 | C19H14FN3O2 | 335.338 | 5 / 1 | 3.1 | Yes |
| 536069 |  CHEMBL3943310 | C23H30N4O3 | 410.518 | 4 / 0 | 3.3 | Yes |
| 5448 |  CHEMBL2158451 | C20H21ClF2N4O3S | 470.92 | 8 / 0 | 1.9 | Yes |
| 5712 |  CHEMBL1773288 | C23H29N5O5S | 487.575 | 8 / 0 | 3.2 | Yes |
| 6163 |  CHEMBL1775177 | C22H28N6O5S | 488.563 | 9 / 0 | 1.9 | Yes |
| 536105 |  CHEMBL3926629 | C29H39N3O3 | 477.649 | 4 / 0 | 4.8 | Yes |
| 536119 |  SCHEMBL2593509 | C20H19N3O2 | 333.391 | 4 / 1 | 3.9 | Yes |
| 7217 |  CHEMBL2322841 | C23H29FN6O6S | 536.579 | 11 / 2 | 4.7 | No |
| 547975 |  CHEMBL3914281 | C23H29FN6O6S | 536.579 | 11 / 2 | 4.7 | No |
| 7519 |  CHEMBL1090879 | C22H37N5O4S | 467.629 | 7 / 1 | 2.1 | Yes |
| 536172 |  SCHEMBL2590505 | C25H28N4O3 | 432.524 | 6 / 1 | 3.9 | Yes |
| 8077 |  CHEMBL3113623 | C23H28N6O4S | 484.575 | 10 / 0 | 3.9 | Yes |
| 536186 |  SCHEMBL2590373 | C25H25N5O4 | 459.506 | 8 / 1 | 4.2 | Yes |
| 8856 |  CHEMBL3113007 | C25H20ClFN4O4S | 526.967 | 9 / 0 | 5.3 | No |
| 8886 |  CHEMBL2086689 | C20H19FN8O | 406.425 | 10 / 0 | 1.5 | Yes |
| 442065 |  CHEMBL3354776 | C26H24F3N3O2 | 467.492 | 7 / 0 | 5.8 | No |
| 9328 |  BDBM50387908 | C21H28N4O3 | 384.48 | 7 / 2 | 4.9 | Yes |
| 9490 |  CHEMBL1956608 | C18H17BrN4O | 385.265 | 4 / 1 | 3.2 | Yes |
| 10217 |  CHEMBL1775175 | C22H25N5O6S | 487.531 | 9 / 0 | 1.9 | Yes |
| 10330 |  CHEMBL1090559 | C24H39N5O5S | 509.666 | 9 / 0 | 2.5 | No |
| 10568 |  CHEMBL3113837 | C23H33FN2O6S | 484.583 | 7 / 0 | 3.5 | Yes |
| 442142 |  CHEMBL3358010 | C23H26F4N4O6S | 562.537 | 13 / 0 | 2.1 | No |
| 11202 |  CHEMBL2336756 | C31H34FN5O4S | 591.702 | 10 / 1 | 5.4 | No |
| 442145 |  CHEMBL3321825 | C24H26N6O2S2 | 494.632 | 9 / 1 | 4.3 | Yes |
| 442149 |  CHEMBL3354805 | C25H21F4N5O | 483.471 | 9 / 2 | 2.6 | Yes |
| 11416 |  CHEMBL1951033 | C22H31N5O6S | 493.579 | 10 / 1 | 2.9 | Yes |
| 12677 |  CID 62707005 | C21H28N4O2S | 400.541 | 7 / 1 | 5.1 | No |
| 12939 |  CHEMBL452070 | C18H21N5O7S | 451.454 | 11 / 1 | 1.6 | No |
| 553323 |  Lysophosphatidylcholine(16:0) | C24H50NO7P | 495.638 | 7 / 1 | 5.6 | No |
| 442205 |  CHEMBL3325849 | C19H22F2N4O6S | 472.464 | 11 / 0 | 2.7 | No |
| 14294 |  CHEMBL1951015 | C20H27N5O3 | 385.468 | 7 / 1 | 3.3 | Yes |
| 14296 |  CHEMBL1684030 | C22H32N6O3 | 428.537 | 6 / 1 | 2.9 | Yes |
| 536362 |  CHEMBL3915823 | C30H36N4O3 | 500.643 | 4 / 0 | 5.2 | No |
| 14372 |  CHEMBL1093453 | C23H38N4O5S | 482.64 | 8 / 0 | 3.0 | Yes |
| 14407 |  CHEMBL2069548 | C18H15BrF2N4O | 421.246 | 6 / 1 | 3.4 | Yes |
| 14643 |  CHEMBL1956596 | C14H16BrN3O | 322.206 | 4 / 2 | 3.0 | Yes |
| 536381 |  SCHEMBL2590331 | C24H25N3O4 | 419.481 | 6 / 1 | 3.7 | Yes |
| 557707 |  SCHEMBL2584661 | C24H25N3O4 | 419.481 | 6 / 1 | 3.7 | Yes |
| 536382 |  SCHEMBL2588390 | C24H25N3O4 | 419.481 | 6 / 1 | 3.7 | Yes |
| 536383 |  SCHEMBL2587935 | C18H14ClN3O2 | 339.779 | 4 / 1 | 3.6 | Yes |
| 442257 |  CHEMBL3358000 | C20H18F4N10O2 | 506.426 | 15 / 0 | 2.6 | No |
| 15804 |  CHEMBL2336758 | C29H37N5O6S | 583.704 | 10 / 1 | 4.7 | No |
| 536387 |  SCHEMBL2590129 | C16H13N3O2S | 311.359 | 5 / 1 | 2.7 | Yes |
| 536402 |  CHEMBL3909975 | C23H28IN3O4 | 537.398 | 5 / 0 | 4.1 | No |
| 16557 |  CHEMBL2086686 | C21H23N7O3 | 421.461 | 9 / 0 | 1.3 | Yes |
| 16831 |  CHEMBL1773292 | C22H26FN5O6S | 507.537 | 9 / 1 | 2.0 | No |
| 17359 |  CHEMBL2181692 | C22H27FN4O5S | 478.539 | 9 / 0 | 3.2 | Yes |
| 17600 |  CHEMBL1775170 | C20H23N5O5S | 445.494 | 8 / 0 | 2.2 | Yes |
| 17606 |  CHEMBL3260513 | C22H18ClN3O2 | 391.855 | 4 / 0 | 4.5 | Yes |
| 459371 |  SCHEMBL2590670 | C19H17N3O2 | 319.364 | 4 / 1 | 3.4 | Yes |
| 18066 |  CHEMBL2312505 | C25H31N5O3 | 449.555 | 7 / 0 | 4.3 | Yes |
| 18440 |  CHEMBL2010836 | C23H25F3N6O | 458.489 | 8 / 0 | 3.6 | Yes |
| 18613 |  CHEMBL1771084 | C21H28N4O2S | 400.541 | 6 / 0 | 2.8 | Yes |
| 18856 |  CHEMBL1684033 | C21H30F2N2O3 | 396.479 | 5 / 1 | 3.8 | Yes |
| 19431 |  CHEMBL3260542 | C23H21ClN2O2S | 424.943 | 4 / 0 | 5.9 | No |
| 536482 |  CHEMBL3966709 | C24H32N4O3 | 424.545 | 4 / 0 | 3.1 | Yes |
| 20289 |  CHEMBL3104889 | C23H18ClN3O5S | 483.923 | 7 / 1 | 3.8 | Yes |
| 442478 |  CHEMBL3321826 | C24H30N4O4S2 | 502.648 | 8 / 0 | 4.1 | No |
| 20784 |  CHEMBL3220233 | C22H24N8O4 | 464.486 | 12 / 0 | 0.7 | No |
| 21543 |  CHEMBL3113017 | C25H19ClF2N4O4S | 544.958 | 10 / 0 | 5.4 | No |
| 21826 |  CHEMBL451796 | C20H21N7O5 | 439.432 | 10 / 0 | 2.8 | Yes |
| 22029 |  CHEMBL1777817 | C22H28N4O4 | 412.49 | 7 / 0 | 3.9 | Yes |
| 536559 |  CHEMBL3949822 | C22H27N3O4 | 397.475 | 5 / 0 | 3.3 | Yes |
| 548146 |  CHEMBL3986478 | C23H27N7O4 | 465.514 | 9 / 2 | 5.1 | No |
| 23101 |  CHEMBL2204984 | C23H24N10O | 456.514 | 9 / 0 | 2.7 | Yes |
| 442584 |  CHEMBL3354781 | C27H24F3N3O2 | 479.503 | 7 / 0 | 5.8 | No |
| 24026 |  CHEMBL3260516 | C20H14Cl2FN3 | 386.251 | 3 / 0 | 5.6 | No |
| 558022 |  SCHEMBL2592501 | C27H32N4O3 | 460.578 | 6 / 1 | 4.7 | Yes |
| 536599 |  SCHEMBL2587600 | C27H32N4O3 | 460.578 | 6 / 1 | 4.7 | Yes |
| 24576 |  CHEMBL1778247 | C22H24FN5O3S | 457.524 | 9 / 1 | 3.6 | Yes |
| 24816 |  CHEMBL2010843 | C23H29N7OS | 451.593 | 7 / 0 | 2.9 | Yes |
| 25010 |  CHEMBL2382408 | C23H30N4O5S | 474.576 | 8 / 0 | 2.6 | Yes |
| 25662 |  CHEMBL2010853 | C23H25F2N3O3S2 | 493.588 | 8 / 0 | 3.3 | Yes |
| 442680 |  CHEMBL3325850 | C20H24F2N4O6S | 486.491 | 11 / 0 | 2.6 | No |
| 442683 |  CHEMBL3325851 | C20H24F2N4O6S | 486.491 | 11 / 0 | 2.6 | No |
| 27274 |  CHEMBL3112979 | C28H25ClN4O4S | 549.042 | 8 / 0 | 5.5 | No |
| 466242 |  CHEMBL3622172 | C23H30FN3O4S | 463.568 | 8 / 0 | 2.4 | Yes |
| 548192 |  CHEMBL3982536 | C21H24FN5O7S | 509.509 | 11 / 1 | 3.5 | No |
| 28468 |  CHEMBL1773295 | C22H25N7O3S | 467.548 | 9 / 0 | 3.2 | Yes |
| 29113 |  CHEMBL2010848 | C22H23F4N7O | 477.468 | 10 / 0 | 2.6 | Yes |
| 29220 |  n-oleoylethanolamine | C20H39NO2 | 325.537 | 2 / 2 | 6.3 | No |
| 29260 |  CHEMBL3260514 | C17H16ClN3O2 | 329.784 | 4 / 0 | 3.3 | Yes |
| 459467 |  SCHEMBL2587403 | C16H18N4O2 | 298.346 | 5 / 1 | 2.1 | Yes |
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