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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL2336756
Molecular formula	C31H34FN5O4S
IUPAC name	2-(9-benzyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-N-(2-fluoro-4-methylsulfonylphenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular weight	591.702
Hydrogen bond acceptor	10
Hydrogen bond donor	1
XlogP	5.4
Synonyms	BDBM50429385
Inchi Key	APOZVOAEAUGHRO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H34FN5O4S/c1-40-28-16-24-27(17-29(28)41-2)34-31(35-30(24)33-26-12-11-23(15-25(26)32)42(3,38)39)36-14-13-21-9-10-22(19-36)37(21)18-20-7-5-4-6-8-20/h4-8,11-12,15-17,21-22H,9-10,13-14,18-19H2,1-3H3,(H,33,34,35)
PubChem CID	71720750
ChEMBL	CHEMBL2336756
IUPHAR	N/A
BindingDB	50429385
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID23357035	BindingDB,ChEMBL
Emax	44.3 %	PMID23357035	ChEMBL

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