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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3260516
Molecular formula	C20H14Cl2FN3
IUPAC name	7-[2-(2-chloro-6-fluorophenyl)ethyl]-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine
Molecular weight	386.251
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50014044
Inchi Key	BHSNKLTYEWRKTN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H14Cl2FN3/c21-14-6-4-13(5-7-14)17-12-25-26-15(10-11-24-20(17)26)8-9-16-18(22)2-1-3-19(16)23/h1-7,10-12H,8-9H2
PubChem CID	90656491
ChEMBL	CHEMBL3260516
IUPHAR	N/A
BindingDB	50014044
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID24751443	BindingDB,ChEMBL
Efficacy	15.0 %	PMID24751443	ChEMBL

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