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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	SCHEMBL2590505
Molecular formula	C25H28N4O3
IUPAC name	4-ethyl-3-[2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,3-benzoxazol-6-yl]-4,5-dihydro-1H-pyridazin-6-one
Molecular weight	432.524
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.9
Synonyms	US8772323, 159 CHEMBL3933234 BDBM180520
Inchi Key	AKNRYYNNBAWWSI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H28N4O3/c1-2-17-16-23(30)27-28-24(17)19-7-10-21-22(15-19)32-25(26-21)18-5-8-20(9-6-18)31-14-13-29-11-3-4-12-29/h5-10,15,17H,2-4,11-14,16H2,1H3,(H,27,30)
PubChem CID	67466238
ChEMBL	CHEMBL3933234
IUPHAR	N/A
BindingDB	180520
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	623.0 nM	, None	BindingDB,ChEMBL

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