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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3915823
Molecular formula	C30H36N4O3
IUPAC name	tert-butyl 4-[cyclopropyl-[4-(5-methyl-4-phenylimidazol-1-yl)benzoyl]amino]piperidine-1-carboxylate
Molecular weight	500.643
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.2
Synonyms	US9469631, 83 BDBM254682 SCHEMBL15507108
Inchi Key	ATSQNOFADIUFLZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H36N4O3/c1-21-27(22-8-6-5-7-9-22)31-20-33(21)24-12-10-23(11-13-24)28(35)34(25-14-15-25)26-16-18-32(19-17-26)29(36)37-30(2,3)4/h5-13,20,25-26H,14-19H2,1-4H3
PubChem CID	89995537
ChEMBL	CHEMBL3915823
IUPHAR	N/A
BindingDB	254682
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	291.0 nM	, None	BindingDB,ChEMBL

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