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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3321826
Molecular formula	C24H30N4O4S2
IUPAC name	tert-butyl 4-[methyl-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]piperidine-1-carboxylate
Molecular weight	502.648
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	4.1
Synonyms	SCHEMBL12506017 tert-butyl 4-(methyl(7-(4-methanesulfonyl-phenyl)thieno[3,2-d]pyrimidin-4-yl)amino)piperidin-1-carboxylate BCTBEGQOLMHQIT-UHFFFAOYSA-N BDBM50100555
Inchi Key	BCTBEGQOLMHQIT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H30N4O4S2/c1-24(2,3)32-23(29)28-12-10-17(11-13-28)27(4)22-21-20(25-15-26-22)19(14-33-21)16-6-8-18(9-7-16)34(5,30)31/h6-9,14-15,17H,10-13H2,1-5H3
PubChem CID	68299301
ChEMBL	CHEMBL3321826
IUPHAR	N/A
BindingDB	50100555
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	76.0 %	PMID25082125	ChEMBL
EC50	39.0 nM	PMID25082125	BindingDB,ChEMBL

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