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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	SCHEMBL2590670
Molecular formula	C19H17N3O2
IUPAC name	5,5-dimethyl-3-(2-phenyl-1,3-benzoxazol-6-yl)-1,4-dihydropyridazin-6-one
Molecular weight	319.364
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.4
Synonyms	US8772323, 21 CHEMBL3899768 BDBM180457
Inchi Key	AYWQMLOVIVPEMG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H17N3O2/c1-19(2)11-15(21-22-18(19)23)13-8-9-14-16(10-13)24-17(20-14)12-6-4-3-5-7-12/h3-10H,11H2,1-2H3,(H,22,23)
PubChem CID	54591867
ChEMBL	CHEMBL3899768
IUPHAR	N/A
BindingDB	180457
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	, None	BindingDB,ChEMBL

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