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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3260542
Molecular formula	C23H21ClN2O2S
IUPAC name	ethyl 2-[7-(4-chlorophenyl)pyrazolo[5,1-b][1,3]thiazol-3-yl]-2-methyl-3-phenylpropanoate
Molecular weight	424.943
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.9
Synonyms	BDBM50013975 SCHEMBL1248199
Inchi Key	BBEDZQIJJGXNCF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H21ClN2O2S/c1-3-28-22(27)23(2,13-16-7-5-4-6-8-16)20-15-29-21-19(14-25-26(20)21)17-9-11-18(24)12-10-17/h4-12,14-15H,3,13H2,1-2H3
PubChem CID	66964831
ChEMBL	CHEMBL3260542
IUPHAR	N/A
BindingDB	50013975
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	53.0 nM	PMID24751443	BindingDB,ChEMBL
Efficacy	70.0 %	PMID24751443	ChEMBL

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