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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3112979
Molecular formula	C28H25ClN4O4S
IUPAC name	5-[2-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-cyclopropylpyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Molecular weight	549.042
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	5.5
Synonyms	BDBM50447719
Inchi Key	BMBHHJOJERDYIV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H25ClN4O4S/c29-21-8-11-23(12-9-21)38(34,35)33-13-1-2-18-7-10-22(16-25(18)33)36-26-15-20(14-24(30-26)17-3-4-17)28-31-27(32-37-28)19-5-6-19/h7-12,14-17,19H,1-6,13H2
PubChem CID	76332169
ChEMBL	CHEMBL3112979
IUPHAR	N/A
BindingDB	50447719
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	130.0 nM	PMID24440299	BindingDB,ChEMBL
Efficacy	93.0 %	PMID24440299	ChEMBL

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