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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3113837
Molecular formula	C23H33FN2O6S
IUPAC name	2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propyl 7-fluoro-5-methylsulfonyl-2,3-dihydroindole-1-carboxylate
Molecular weight	484.583
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.5
Synonyms	BDBM50446700
Inchi Key	AOSPHWIRDWKZNF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H33FN2O6S/c1-15(16-6-9-25(10-7-16)21(27)32-23(2,3)4)14-31-22(28)26-11-8-17-12-18(33(5,29)30)13-19(24)20(17)26/h12-13,15-16H,6-11,14H2,1-5H3
PubChem CID	76328564
ChEMBL	CHEMBL3113837
IUPHAR	N/A
BindingDB	50446700
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6.8 nM	PMID24508142	BindingDB,ChEMBL

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