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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3104889
Molecular formula	C23H18ClN3O5S
IUPAC name	4-chloro-N-[3-(2-cyclopropyl-6-methyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Molecular weight	483.923
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.8
Synonyms	BDBM50445498
Inchi Key	BCLHNZKRVLWHLN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H18ClN3O5S/c1-13-11-19-20(23(29)27(22(19)28)16-7-8-16)21(25-13)32-17-4-2-3-15(12-17)26-33(30,31)18-9-5-14(24)6-10-18/h2-6,9-12,16,26H,7-8H2,1H3
PubChem CID	72945518
ChEMBL	CHEMBL3104889
IUPHAR	N/A
BindingDB	50445498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	15.0 nM	PMID24332491	BindingDB,ChEMBL
Efficacy	111.0 %	PMID24332491	ChEMBL

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