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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3321825
Molecular formula	C24H26N6O2S2
IUPAC name	N-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-amine
Molecular weight	494.632
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	4.3
Synonyms	APQKTIVJRSIVFG-UHFFFAOYSA-N N-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-7-(4-methanesulfonyl-phenyl)thieno[3,2-d]pyrimidin-4-amine SCHEMBL12506012
Inchi Key	APQKTIVJRSIVFG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H26N6O2S2/c1-3-16-12-25-24(26-13-16)30-10-8-18(9-11-30)29-23-22-21(27-15-28-23)20(14-33-22)17-4-6-19(7-5-17)34(2,31)32/h4-7,12-15,18H,3,8-11H2,1-2H3,(H,27,28,29)
PubChem CID	57414347
ChEMBL	CHEMBL3321825
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	49.0 %	PMID25082125	ChEMBL

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