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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3113007
Molecular formula	C25H20ClFN4O4S
IUPAC name	5-[2-chloro-6-[[1-(3-fluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Molecular weight	526.967
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	5.3
Synonyms	BDBM50447710
Inchi Key	AMGKJGKFZBRFFL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H20ClFN4O4S/c26-22-11-17(25-29-24(30-35-25)16-6-7-16)12-23(28-22)34-19-9-8-15-3-2-10-31(21(15)14-19)36(32,33)20-5-1-4-18(27)13-20/h1,4-5,8-9,11-14,16H,2-3,6-7,10H2
PubChem CID	76332171
ChEMBL	CHEMBL3113007
IUPHAR	N/A
BindingDB	50447710
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	320.0 nM	PMID24440299	BindingDB,ChEMBL
Efficacy	90.0 %	PMID24440299	ChEMBL

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