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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL2086686
Molecular formula	C21H23N7O3
IUPAC name	2-cyanopropan-2-yl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Molecular weight	421.461
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	1.3
Synonyms	BDBM50420840 SCHEMBL1448281
Inchi Key	AXCPODYQWVLWMM-OAHLLOKOSA-N
Inchi ID	InChI=1S/C21H23N7O3/c1-15-12-27(20(29)31-21(2,3)14-23)6-7-28(15)19-25-10-18(11-26-19)30-13-16-4-5-24-9-17(16)8-22/h4-5,9-11,15H,6-7,12-13H2,1-3H3/t15-/m1/s1
PubChem CID	51030529
ChEMBL	CHEMBL2086686
IUPHAR	N/A
BindingDB	50420840
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	54.0 nM	PMID22545772	BindingDB,ChEMBL
Intrinsic activity	125.0 %	PMID22545772	ChEMBL

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