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Name | Histamine H4 receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Hrh4 |
Synonym | GPCR105 H4 receptor H4R HH4R |
Disease | N/A for non-human GPCRs |
Length | 391 |
Amino acid sequence | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS |
UniProt | Q91ZY2 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5657 |
IUPHAR | 265 |
DrugBank | N/A |
You can:
GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
46823 | JNJ-39758979 | C11H19N5 | 221.308 | 5 / 2 | 0.7 | Yes |
61586 | SCHEMBL604437 | C18H25N5O | 327.432 | 6 / 2 | 1.3 | Yes |
68320 | CHEMBL1083162 | C23H26FN5O | 407.493 | 5 / 3 | 4.0 | Yes |
553658 | 1-Methylhistamine | C6H11N3 | 125.175 | 2 / 1 | -0.6 | Yes |
107814 | JMC516547 Compound 5 | C15H16N6 | 280.335 | 6 / 2 | 1.0 | Yes |
123589 | CHEMBL2376803 | C16H22N6 | 298.394 | 6 / 2 | 2.1 | Yes |
124517 | JNJ-7777120 | C14H16ClN3O | 277.752 | 2 / 1 | 2.3 | Yes |
553934 | H4 antagonist 48 | C11H11BrN8 | 335.169 | 7 / 1 | 0.5 | Yes |
140555 | PF-3893787 | C13H22N6 | 262.361 | 6 / 3 | 1.1 | Yes |
169714 | CHEMBL2376804 | C14H18N6 | 270.34 | 6 / 2 | 1.0 | Yes |
173138 | SCHEMBL4054703 | C22H29N5 | 363.509 | 5 / 2 | 3.7 | Yes |
178950 | UNII-8U5620H545 | C17H21N5 | 295.39 | 5 / 2 | 2.2 | Yes |
196195 | SCHEMBL606676 | C19H25N5 | 323.444 | 5 / 2 | 2.9 | Yes |
204900 | CHEMBL1086105 | C24H26FN5O | 419.504 | 5 / 2 | 4.1 | Yes |
527516 | CHEMBL3805361 | C19H24N6S | 368.503 | 4 / 3 | 2.8 | Yes |
527521 | CHEMBL3805220 | C19H24N6S | 368.503 | 4 / 3 | 2.8 | Yes |
563988 | CHEMBL1632411 | C15H19N3O | 257.337 | 3 / 2 | 2.8 | Yes |
232084 | histamine | C5H9N3 | 111.148 | 2 / 2 | -0.7 | Yes |
494500 | CHEMBL3628042 | C16H19ClN6 | 330.82 | 6 / 1 | 2.8 | Yes |
554553 | imetit | C6H10N4S | 170.234 | 3 / 3 | 0.2 | Yes |
266830 | CHEMBL2376800 | C13H18N6 | 258.329 | 6 / 2 | 0.9 | Yes |
276031 | CHEMBL2376801 | C14H20N6 | 272.356 | 6 / 2 | 1.2 | Yes |
276958 | A-846714 | C16H18N6 | 294.362 | 6 / 1 | 1.5 | Yes |
554666 | Thioperamide | C15H24N4S | 292.445 | 2 / 2 | 2.4 | Yes |
566367 | clozapine | C18H19ClN4 | 326.828 | 3 / 1 | 3.1 | Yes |
300483 | CHEMBL503605 | C13H14ClN3O | 263.725 | 2 / 2 | 1.8 | Yes |
311761 | UNII-Q598HK01AO | C17H21N5 | 295.39 | 5 / 2 | 2.1 | Yes |
554914 | 1-[4-(1H-indazol-4-yl)butyl]-3-methylthiourea | C13H18N4S | 262.375 | 2 / 3 | 2.3 | Yes |
332470 | CHEMBL1935574 | C16H17N5O | 295.346 | 6 / 2 | 1.7 | Yes |
554928 | clobenpropit | C14H17ClN4S | 308.828 | 3 / 2 | 3.0 | Yes |
336614 | 4-Methylhistamine | C6H11N3 | 125.175 | 2 / 2 | -0.2 | Yes |
349087 | CHEMBL3236553 | C13H21N5 | 247.346 | 5 / 2 | 1.3 | Yes |
568516 | CHEMBL1632412 | C16H21N3O | 271.364 | 3 / 2 | 3.2 | Yes |
360399 | CHEMBL1082296 | C25H31FN4O | 422.548 | 5 / 2 | 4.5 | Yes |
360404 | CHEMBL1084810 | C25H31FN4O | 422.548 | 5 / 2 | 4.5 | Yes |
367310 | CHEMBL1081680 | C16H25N5 | 287.411 | 5 / 2 | 2.2 | Yes |
532357 | CHEMBL3805437 | C12H18N6 | 246.318 | 3 / 3 | 0.6 | Yes |
532361 | CHEMBL3804906 | C12H18N6 | 246.318 | 3 / 3 | 0.6 | Yes |
555269 | (R)-alpha-Methylhistamine | C6H11N3 | 125.175 | 2 / 2 | -0.3 | Yes |
570243 | CHEMBL1632413 | C14H17ClN4O | 292.767 | 3 / 2 | 2.5 | Yes |
419075 | CHEMBL3236568 | C11H19N5 | 221.308 | 5 / 2 | 0.9 | Yes |
570708 | CHEMBL1632414 | C14H17ClN4O | 292.767 | 4 / 2 | 2.9 | Yes |
430876 | SCHEMBL606792 | C17H20FN5 | 313.38 | 6 / 2 | 2.3 | Yes |
433075 | SCHEMBL603142 | C18H23N5 | 309.417 | 5 / 2 | 2.6 | Yes |
440000 | SCHEMBL606788 | C17H21N5 | 295.39 | 5 / 2 | 2.2 | Yes |
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