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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Mus musculus (Mouse)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProt	Q91ZY2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5657
IUPHAR	265
DrugBank	N/A

Ligand

Name	PF-3893787
Molecular formula	C13H22N6
IUPAC name	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
Molecular weight	262.361
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	1.1
Synonyms	CHEMBL1915540 GTPL8985 ZPL-389 BDBM50356884 PF-03893787 ZPL3893787 D02DTQ SCHEMBL12604990 N'-(cyclopropylmethyl)-6-[(3R)-3-methylaminopyrrolidin-1-yl]pyrimidine-2,4-diamine ZPL-3893787 PF-3826719 2,4-Pyrimidinediamine, N4-(cyclopropylmethyl)-6-((3R)-3-(methylamino)-1-pyrrolidinyl)- D65H9YE9VU UNII-D65H9YE9VU 943057-12-3 PF 3893787 ZPL389 [ Show all ]
Inchi Key	ISBHYKVAFKTATD-SNVBAGLBSA-N
Inchi ID	InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
PubChem CID	24745335
ChEMBL	CHEMBL1915540
IUPHAR	8985
BindingDB	50356884
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	20.89 nM	PMID21920751, PMID25993395	BindingDB,ChEMBL
Ki	21.0 nM	PMID25993395	BindingDB
Ki	54.95 nM	PMID23558237	ChEMBL
Ki	55.0 nM	PMID23558237	BindingDB

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