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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Mus musculus (Mouse)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProt	Q91ZY2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5657
IUPHAR	265
DrugBank	N/A

Ligand

Name	4-Methylhistamine
Molecular formula	C6H11N3
IUPAC name	2-(5-methyl-1H-imidazol-4-yl)ethanamine
Molecular weight	125.175
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	-0.2
Synonyms	2-(5-Methyl-1H-imidazol-4-yl)ethylamine # 4-Methyl-1H-imidazole-5-ethanamine 54ST71P9EE BRD-K70821460-300-01-6 GTPL1269 PDSP1_000400 1H-Imidazole-4-ethanamine, 5-methyl- 2-(5-Methyl-4-imidazolyl)ethylamine Dihydrochloride 5(4)-Methylhistamine Dihydrochloride AKOS012036768 LS-78033 SCHEMBL11452941 2-(5-methyl-1H-imidazol-4-yl)ethan-1-amine 36507-31-0 5-Methyl-1H-imidazole-4-ethanamine Hydrochloride AN-9442 EN300-82322 MolPort-006-803-984 UNII-54ST71P9EE 2-(5-METHYL-3H-IMIDAZOL-4-YL)-ETHYLAMINE AB45417 C17929 IMIDAZOLE, 4-(2-AMINOETHYL)-5-METHYL- PDSP2_000398 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHAN-1-AMINE 5-(2-Aminoethyl)-4-methylimidazole AKOS022477289 CHEMBL275443 MCULE-8926131767 SCHEMBL606803 2-(5-methyl-1H-imidazol-4-yl)ethanamine 4-Methyl Histamine Dihydrochloride 5-Methylhistamine BDBM22880 FT-0736440 p-methylhistamine ZINC3605034 1H-Imidazo-4-ethanamine, 5-methyl- 2-(5-Methyl-4-imidazolyl)ethylamine 5(4)-Methylhistamine AC1L1XS2 CHEBI:74760 L000072 SC-51140 2-(4-METHYL-1H-IMIDAZOL-5-YL)ETHANAMINE 36376-47-3 (di-hydrochloride) 5-Methyl-1H-imidazole-4-ethanamine ALBB-030504 D02SQF Methylhistamine-4 UGYXPZQILZRKJJ-UHFFFAOYSA-N [ Show all ]
Inchi Key	UGYXPZQILZRKJJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3/c1-5-6(2-3-7)9-4-8-5/h4H,2-3,7H2,1H3,(H,8,9)
PubChem CID	37463
ChEMBL	CHEMBL275443
IUPHAR	1269
BindingDB	22880
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1584.89 nM	PMID21044842	ChEMBL

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