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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Mus musculus (Mouse)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProt	Q91ZY2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5657
IUPHAR	265
DrugBank	N/A

Ligand

Name	(R)-alpha-Methylhistamine
Molecular formula	C6H11N3
IUPAC name	(2R)-1-(1H-imidazol-5-yl)propan-2-amine
Molecular weight	125.175
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	-0.3
Synonyms	alpha-methylhistamine, (R)-isomer LS-191796 PDSP2_000507 RAMH (R)-alpha-MeHA 75614-87-8 BDBM22904 D04HEZ NCGC00024656-03 R(-)-alpha-METHYLHISTAMINE Tocris-0569 (2R)-1-(1H-imidazol-5-yl)propan-2-amine (R)alpha-Me-histamine AKOS006343508 CCG-204707 Lopac0_000618 PDSP1_000541 r(-)alpha methylhistamine [3H](R)-alpha-methylhistamine (R)-(-)-alpha-methylhistamine Alpha-Methylhistamine-R CHEMBL268229 NCGC00024656-01 PDSP2_000533 SCHEMBL4155130 4491AJ AC1L4GIC BDBM50215536 GTPL1236 NCGC00024656-04 R(-)-\|A-Methyl Histamine Dihydrochloride XNQIOISZPFVUFG-RXMQYKEDSA-N (2R)-1-(3H-imidazol-4-yl)propan-2-amine (\|AR)-\|A-Methyl-1H-imidazole-4-ethanamine Dihydrochloride Alpha Methylhistamine CHEBI:73337 LS-177199 PDSP1_000542 r-alpha-methylhistamine [3H]-R-alpha-Methylhistamine (R)-2-(3H-Imidazol-4-yl)-1-methyl-ethylamine 1H-Imidazole-4-ethanamine, alpha-methyl-, (alphaR)- Alpha-Methylhistane-R D03SAM NCGC00024656-02 PDSP2_000539 SCHEMBL73663 (2R)-1-(1H-imidazol-4-yl)propan-2-amine (R)-[3H]alpha-methylhistamine AC1Q299Z C6H11N3 GTPL1237 PDSP1_000535 R(-)-\|A-Methyl-1H-imidazole-5-ethanamine Dihydrochloride ZINC3872814 (R)-(-)-4-(2-aminopropyl)imidazole [ Show all ]
Inchi Key	XNQIOISZPFVUFG-RXMQYKEDSA-N
Inchi ID	InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
PubChem CID	156615
ChEMBL	CHEMBL268229
IUPHAR	1237, 1236
BindingDB	22904, 50215536
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	398.107 nM	PMID11561071	IUPHAR

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