You can:
Name | Histamine H4 receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Hrh4 |
Synonym | GPCR105 H4 receptor H4R HH4R |
Disease | N/A for non-human GPCRs |
Length | 391 |
Amino acid sequence | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS |
UniProt | Q91ZY2 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5657 |
IUPHAR | 265 |
DrugBank | N/A |
Name | CHEMBL503605 |
---|---|
Molecular formula | C13H14ClN3O |
IUPAC name | (5-chloro-1H-indol-2-yl)-piperazin-1-ylmethanone |
Molecular weight | 263.725 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 1.8 |
Synonyms | (5-Chloro-1H-indol-2-yl)-piperazin-1-yl-methanone JNJ 7777120 analogue, 4 AKOS016342960 ZINC32500347 (5-chloro-1H-indol-2-yl)(piperazino)methanone [ Show all ] |
Inchi Key | RNGVSSIIHLHHSN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C13H14ClN3O/c14-10-1-2-11-9(7-10)8-12(16-11)13(18)17-5-3-15-4-6-17/h1-2,7-8,15-16H,3-6H2 |
PubChem CID | 21638785 |
ChEMBL | CHEMBL503605 |
IUPHAR | N/A |
BindingDB | 26391 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 17.78 nM | PMID18817367 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417