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Name | Histamine H4 receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Hrh4 |
Synonym | GPCR105 H4 receptor H4R HH4R |
Disease | N/A for non-human GPCRs |
Length | 391 |
Amino acid sequence | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS |
UniProt | Q91ZY2 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5657 |
IUPHAR | 265 |
DrugBank | N/A |
Name | CHEMBL2376801 |
---|---|
Molecular formula | C14H20N6 |
IUPAC name | 7-ethyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine |
Molecular weight | 272.356 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 1.2 |
Synonyms | BDBM50433356 SCHEMBL14895496 |
Inchi Key | QEDDBMMRWNQKSG-SNVBAGLBSA-N |
Inchi ID | InChI=1S/C14H20N6/c1-3-9-6-11-12(17-7-9)13(19-14(15)18-11)20-5-4-10(8-20)16-2/h6-7,10,16H,3-5,8H2,1-2H3,(H2,15,18,19)/t10-/m1/s1 |
PubChem CID | 71525679 |
ChEMBL | CHEMBL2376801 |
IUPHAR | N/A |
BindingDB | 50433356 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 85.0 nM | PMID23558237 | BindingDB |
Ki | 85.11 nM | PMID23558237 | ChEMBL |
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