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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	Ziprasidone
Molecular formula	C21H21ClN4OS
IUPAC name	5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
Molecular weight	412.936
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.0
Synonyms	4770-EP2316836A1 NCGC00263539-03 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one Tox21_112194 ZINC538550 AB00639925_05 Ziprasidone solution, 1.0 mg/mL in 1,2-dimethoxyethane, ampule of 1 mL, certified reference material API0004647 CP-88059-1 D0E0NJ FT-0654208 4770-EP2272537A2 I14-0766 MLS000759435 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indole-2-one SC-22049 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one UNII-6UKA5VEJ6X 6UKA5VEJ6X ziprasidona AC1L1U27 ziprazidone BIDD:GT0042 CP 88059-01 CP-8805927 DB00246 138982-67-9 (hydrochloride monohydrate) Geodon (TN) 4770-EP2280010A2 4770-EP2301936A1 NCGC00186050-01 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one (Ziprasidone) TC-5280 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one Zeldox AB00639925-02 Ziprasidone hydrochloride AM90310 CAS-146939-27-7 CP-88,059-01 CZ0013 DSSTox_RID_77186 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro- HSDB 7745 L000659 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one NCGC00263539-05 5-[2-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydroindol-2-one Tox21_112194_1 Zipradon AB00639925_06 Ziprasidone [INN:BAN] BC643069 CHEMBL708 CP-88059-27 D0R1JV FT-0655916 4770-EP2272841A1 MolPort-003-850-885 5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one SCHEMBL28028 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-indolin-2-one VU0286234-2 883Z936 AJ-23401 C07568 CP 88059;CP-88059;CP88059 CPD000466328 DSSTox_CID_3753 146939-27-7 Geodon Oral 4770-EP2298731A1 4770-EP2308875A1 NCGC00263539-01 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one(Norastemizole) TL8000889 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one Zeldox (TN) AB00639925-04 Ziprasidone mesylate trihydrate AN-16930 CHEBI:10119 CP-88,059-1 D08687 DTXSID4023753 4169AH HY-14542 LS-83744 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one SAM001246607 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one Tox21_113525 6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one Zipradon (TN) AC-23360 ziprasidonum BDBM50048803 CP 88059 CP-880591 122883-93-6,138982-67-9(ClH.H2O),146939-27-7(freebase) Geodon 4770-EP2275420A1 4770-EP2298776A1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one SMR000466328 5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one W-5149 A808568 Ziprasidone (INN) AKOS015900383 C21H21ClN4OS CP-88,059 CS-1071 DSSTox_GSID_23753 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro- GTPL59 [ Show all ]
Inchi Key	MVWVFYHBGMAFLY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
PubChem CID	60854
ChEMBL	CHEMBL708
IUPHAR	59
BindingDB	50048803
DrugBank	DB00246
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
215511	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
215545	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
215508	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
215536	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
215535	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
215499	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
215496	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
215522	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
215528	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
215498	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
215513	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
215514	5-hydroxytryptamine receptor 5A	P47898	HTR5A	Homo sapiens (Human)	357
215500	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
215504	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
215537	5-hydroxytryptamine receptor 7	P32304	Htr7	Mus musculus (Mouse)	448
215510	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
215532	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
215526	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
215505	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
215542	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450

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