Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
269	CHEMBL539358	C19H25ClFNO2	353.862	4 / 2	N/A	N/A
4231	CHEMBL418160	C27H32ClFN4O	483.028	3 / 1	5.1	No
4544	CHEMBL285712	C24H25FN2O	376.475	3 / 1	4.7	Yes
459266	CHEMBL137163	C17H24N2O	272.392	3 / 1	2.4	Yes
6825	CHEMBL540322	C16H22Cl3NO	350.708	2 / 1	N/A	N/A
6869	CHEMBL13632	C17H17BrClNO	366.683	2 / 1	4.7	Yes
7460	CHEMBL334466	C25H28FNO5	441.499	7 / 2	N/A	N/A
9740	CHEMBL430151	C21H22ClFN2O	372.868	3 / 1	4.3	Yes
459302	CHEMBL139578	C20H25NO	295.426	2 / 0	4.7	Yes
10042	CHEMBL143075	C20H25N5OS2	415.574	7 / 2	3.8	Yes
10978	EF-7412	C22H33N5O4S	463.597	7 / 1	1.5	Yes
555522	Epidepride	C16H23IN2O3	418.275	4 / 1	2.1	Yes
11288	CHEMBL439609	C18H30N2O2	306.45	4 / 1	N/A	N/A
12313	CHEMBL13051	C28H34ClFN4O	497.055	3 / 1	5.5	No
12938	CHEMBL267304	C25H29FN4O	420.532	3 / 1	3.8	Yes
14820	CHEMBL138281	C21H21F4NO	379.399	6 / 0	4.8	Yes
459364	CHEMBL137250	C24H27NO	345.486	2 / 1	5.0	Yes
20181	imipramine	C19H24N2	280.415	2 / 0	4.8	Yes
459401	CHEMBL539567	C20H23ClFNO	347.858	3 / 0	4.6	Yes
21653	CHEMBL136495	C24H28FNO5	429.488	7 / 2	N/A	N/A
555567	(+)-sulpiride	C15H23N3O4S	341.426	6 / 2	0.6	Yes
555568	Levosulpiride	C15H23N3O4S	341.426	6 / 2	0.6	Yes
23365	sulpiride	C15H23N3O4S	341.426	6 / 2	0.6	Yes
23455	CHEMBL137502	C19H26N2O2	314.429	4 / 1	N/A	N/A
459438	CHEMBL343926	C18H23NO2	285.387	3 / 1	2.8	Yes
26210	CHEMBL539567	C20H24Cl2FNO	384.316	3 / 1	N/A	N/A
26768	CHEMBL268971	C29H34ClFN4O	509.066	3 / 0	5.5	No
27561	CHEMBL57514	C25H32FN3O2SSi	485.693	5 / 1	N/A	N/A
459477	CHEMBL424281	C23H25NO	331.459	2 / 0	5.4	No
555612	Clebopride	C20H24ClN3O2	373.881	4 / 2	3.2	Yes
34704	CHEMBL193854	C23H26FN3O2	395.478	5 / 1	4.1	Yes
459564	CHEMBL545552	C24H26FNO	363.476	3 / 0	5.2	No
459568	CHEMBL136064	C23H25FN2O	364.464	3 / 1	4.7	Yes
41534	CHEMBL543917	C18H25ClF3NO2	379.848	6 / 2	N/A	N/A
459595	138030-84-9	C20H25NO	295.426	2 / 0	3.8	Yes
42547	CHEMBL136381	C18H23FN2O2	318.392	5 / 1	N/A	N/A
459648	CHEMBL543437	C21H24F3NO	363.424	5 / 1	4.6	Yes
48385	CHEMBL136789	C21H25NOS	339.497	3 / 0	4.3	Yes
459660	CHEMBL545549	C17H25NOS	291.453	3 / 0	3.9	Yes
459662	CHEMBL554678	C23H31NO	337.507	2 / 0	5.0	Yes
49441	CHEMBL136701	C22H30FNO2	359.485	4 / 2	N/A	N/A
459663	CHEMBL80656	C22H29NO	323.48	2 / 0	4.7	Yes
49623	CHEMBL369984	C23H26FN3O2	395.478	5 / 1	4.1	Yes
459668	CHEMBL555975	C21H31NO	313.485	2 / 0	4.7	Yes
459670	CHEMBL1184322	C16H23NO	245.366	2 / 0	2.9	Yes
51090	CHEMBL558819	C22H27ClFNO3	407.91	5 / 1	N/A	N/A
52266	CHEMBL545081	C27H31ClFNO2	455.998	4 / 1	N/A	N/A
52635	CHEMBL267549	C25H28ClFN4O	454.974	3 / 1	4.4	Yes
55362	CHEMBL555443	C20H25ClFNO	349.874	3 / 2	N/A	N/A
459745	CHEMBL545781	C22H27NO3	353.462	4 / 0	3.7	Yes
57170	CHEMBL194844	C24H29N3O2	391.515	4 / 1	4.4	Yes
59770	CHEMBL544147	C20H25ClFNO2	365.873	4 / 2	N/A	N/A
459772	CHEMBL555865	C20H23ClFNO	347.858	3 / 0	5.4	No
60991	CHEMBL136781	C20H22FNO	311.4	3 / 0	3.9	Yes
555714	spiperone	C23H26FN3O2	395.478	5 / 1	3.0	Yes
459794	CHEMBL545081	C27H30FNO2	419.54	4 / 0	5.4	No
66460	CHEMBL197665	C23H28N4O	376.504	4 / 2	4.0	Yes
459830	CHEMBL136877	C17H25NO2	275.392	3 / 1	2.5	Yes
459831	CHEMBL136205	C23H29NO2	351.49	3 / 0	5.0	Yes
70292	CHEMBL423353	C21H28FNO5	393.455	7 / 2	N/A	N/A
71696	CHEMBL198224	C24H28N4O2	404.514	4 / 2	3.6	Yes
71697	CHEMBL198216	C24H28N4O2	404.514	4 / 2	3.6	Yes
71699	CHEMBL198070	C24H28N4O2	404.514	4 / 2	3.6	Yes
459908	CHEMBL136381	C18H21FN2O	300.377	4 / 0	3.2	Yes
459913	CHEMBL337148	C21H25NO2S	355.496	4 / 0	2.9	Yes
78316	CHEMBL544146	C20H26ClNO	331.884	2 / 1	N/A	N/A
78733	CHEMBL343838	C23H26N6OS	434.562	6 / 2	4.2	Yes
78987	CHEMBL136622	C23H30FNO	355.497	3 / 1	5.1	No
81087	CHEMBL56571	C26H32FN3OSi	449.645	3 / 1	N/A	N/A
459954	CHEMBL136388	C21H25NO2	323.436	3 / 1	2.9	Yes
83449	CHEMBL137163	C17H26N2O2	290.407	4 / 2	N/A	N/A
83589	CHEMBL37385	C24H25FN2O	376.475	3 / 1	4.7	Yes
555796	(A+/-)-Quinpirole dihydrochloride	C13H21N3	219.332	2 / 1	2.3	Yes
555799	QUINPIROLE	C13H21N3	219.332	2 / 1	2.3	Yes
88698	CHEMBL139102	C15H24N2O2	264.369	4 / 1	N/A	N/A
89291	CHEMBL543438	C16H19ClF5NO	371.776	7 / 1	N/A	N/A
89752	CHEMBL194240	C23H26ClN3O2	411.93	4 / 1	4.6	Yes
460026	CHEMBL334466	C21H24FNO	325.427	3 / 0	3.9	Yes
91942	CHEMBL544372	C23H28BrNO	414.387	2 / 1	N/A	N/A
460040	CHEMBL543206	C19H28N2O	300.446	3 / 0	3.2	Yes
92893	CHEMBL137085	C21H28FNO5	393.455	7 / 2	N/A	N/A
94368	CHEMBL47482	C15H15N	209.292	1 / 1	2.7	Yes
95717	CHEMBL170310	C16H26IN3O4S	483.365	6 / 2	N/A	N/A
460069	CHEMBL545546	C20H24FNO	313.416	3 / 1	3.9	Yes
99822	CHEMBL545549	C17H26ClNOS	327.911	3 / 1	N/A	N/A
101529	UNII-UGT5535REQ	C17H18ClNO	287.787	2 / 1	4.0	Yes
102657	CHEMBL136068	C21H24F3NO2	379.423	6 / 1	N/A	N/A
104260	CHEMBL170622	C15H23IN2O4S2	486.383	6 / 2	N/A	N/A
104621	CHEMBL539042	C21H28ClNO2	361.91	3 / 2	N/A	N/A
104928	CHEMBL136702	C18H27NO2	289.419	3 / 1	2.9	Yes
105463	Rimcazole	C21H27N3	321.468	2 / 1	3.9	Yes
107695	CHEMBL335327	C16H22FNO	263.356	3 / 0	3.5	Yes
108110	CHEMBL423355	C18H24N2O	284.403	2 / 1	3.6	Yes
108218	CHEMBL383396	C24H28N4O	388.515	3 / 2	3.4	Yes
109133	SERTINDOLE	C24H26ClFN4O	440.947	3 / 1	4.1	Yes
111136	CHEMBL300786	C24H26FN3O	391.49	3 / 1	3.9	Yes
112065	CHEMBL337124	C23H27FN2O6	446.475	9 / 3	N/A	N/A
113580	CHEMBL137563	C20H31NO	301.474	2 / 0	5.1	No
115624	CHEMBL136963	C25H30FNO5	443.515	7 / 2	N/A	N/A
117900	CHEMBL541603	C19H30ClNO4	371.902	5 / 1	N/A	N/A

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417