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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL137563
Molecular formula	C20H31NO
IUPAC name	4-[(4-tert-butylphenoxy)methyl]-1-(cyclopropylmethyl)piperidine
Molecular weight	301.474
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	5.1
Synonyms	4-(4-tert-Butyl-phenoxymethyl)-1-cyclopropylmethyl-piperidine BDBM50002205 ZINC13730022 4-[(4-tert-butylphenoxy)methyl]-1-(cyclopropylmethyl)piperidine
Inchi Key	HFMGOZRRGHHPQV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H31NO/c1-20(2,3)18-6-8-19(9-7-18)22-15-17-10-12-21(13-11-17)14-16-4-5-16/h6-9,16-17H,4-5,10-15H2,1-3H3
PubChem CID	10357512
ChEMBL	CHEMBL137563
IUPHAR	N/A
BindingDB	50002205
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3154.0 nM	PMID1360026	BindingDB,ChEMBL

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