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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL137250
Molecular formula	C24H27NO
IUPAC name	2-(1-benzylpiperidin-4-yl)-1-naphthalen-2-ylethanol
Molecular weight	345.486
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.0
Synonyms	BDBM50002270 SCHEMBL7380819 2-(1-Benzyl-piperidin-4-yl)-1-naphthalen-2-yl-ethanol;0.25hydrate CHEMBL1180666
Inchi Key	AXUFIAPYKHZLJF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27NO/c26-24(23-11-10-21-8-4-5-9-22(21)17-23)16-19-12-14-25(15-13-19)18-20-6-2-1-3-7-20/h1-11,17,19,24,26H,12-16,18H2
PubChem CID	10043199
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50002270
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3329.0 nM	PMID1360026	BindingDB

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