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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL423355
Molecular formula	C18H24N2O
IUPAC name	5-[[1-(cyclopropylmethyl)piperidin-4-yl]methoxy]-1H-indole
Molecular weight	284.403
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50002192 ZINC13730197 5-(1-Cyclopropylmethyl-piperidin-4-ylmethoxy)-1H-indole
Inchi Key	GYBWSNJGOJUGRI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H24N2O/c1-2-14(1)12-20-9-6-15(7-10-20)13-21-17-3-4-18-16(11-17)5-8-19-18/h3-5,8,11,14-15,19H,1-2,6-7,9-10,12-13H2
PubChem CID	10062442
ChEMBL	CHEMBL423355
IUPHAR	N/A
BindingDB	50002192
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2349.0 nM	PMID1360026	BindingDB,ChEMBL

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