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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	Levosulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- (9CI) S 7771 C-20361 SCHEMBL70112 CHEMBL267044 Sulpiride [L-(-)] DSSTox_RID_80052 Tox21_110933_1 HMS3263I20 L-Sulpiride (-)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-o-anisamide Levosulpiride (Levogastrol) (S)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-methoxy-5-sulfamoylbenzamide MLS001424014 NCGC00024853-01 AK163543 Nexipride PDSP1_000620 BGRJTUBHPOOWDU-NSHDSACASA-N S-Sulpiride CAS_15676-16-1 SR-01000076136-2 CS-4581 Sulpiride-S GP2472 UNII-JTG7R315LK I0821 Levopraid (TN) (S)-(-)-N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Levosulpride 23672-07-3 N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide AB00639965-08 NCGC00024853-04 ANW-42196 BCP9000853 PDSP2_000616 BRD-K51671335-001-01-5 SBB058180 CHEBI:64119 ST50319539 DSSTox_CID_22583 Tocris-0895 HMS2089E04 K-6442 (-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide (S)-(-)-Sulpiride, VETRANAL(TM), analytical standard MFCD00055220 5-HT6 Serotonin Receptor from rat, recombinant, expressed in HEK 293 cells, membrane suspension NCGC00015966-10 AC-6821 NCGC00024853-09 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- S-(-)-N-(1-Ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide CAS-15676-16-1 SMR000466366 CL-004 SULPIRIDE,(+) DTXSID0042583 Tox21_501089 HMS3266P14 Levogastrol (-)-Sulpiride Levosulpiride [INN] (S)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide MolPort-003-930-513 NCGC00024853-02 AKOS007930553 PDSP1_001649 Biomol-NT_000030 s2104 CC-29928 SR-01000597436 CTK8B3281 SW197477-2 GTPL958 ZINC57008 J-015181 Levopride (S)-(-)-sulpiride Lopac0_001089 5-(Aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-benzamide N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-methoxy-5-sulfamoylbenzamide AB00639965_09 NCGC00024853-05 API0003164 BDBM81774 RV-12309 BRD-K51671335-001-04-9 SC-76846 Sulpid DSSTox_GSID_42583 Tox21_110933 HMS2232P10 KS-5103 (-)-N-(((S)-1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Levosulpiride (INN) (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide MLS000759490 672L073 NCGC00016718-01 AC1LELQ0 NCGC00261774-01 PDSP1_000516 BG0325 S-(-)-Sulpiride CAS-23672-07-3 SR-01000076136 CPD000466366 Sulpiride-l EU-0101089 UNII-7MNE9M8287 component BGRJTUBHPOOWDU-NSHDSACASA-N HY-B1059 Levopraid (S)-(-)-5-aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Levosulpiridum (S)-sulpiride N-[((2S)-1-ethylpyrrolidin-2-yl)methyl](6-methoxy-3-sulfamoylphenyl)carboxamid e AB00639965-06 NCGC00024853-03 AKOS015897363 PDSP2_000514 BPBio1_001221 SAM001246703 CCG-100847 SR-01000597436-1 D07312 TL8001954 HMS2051A08 JTG7R315LK Levosulpirida (S)-(-)-Sulpiride, >=98% (titration) LP01089 5-(Aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy-benzamide NC00097 AB1009626 NCGC00024853-06 BCP0726000072 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-NSHDSACASA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
PubChem CID	688272
ChEMBL	CHEMBL267044
IUPHAR	958
BindingDB	81774
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	34.0 nM	PMID2895008	BindingDB
Ki	1473.0 nM	PMID9021894	BindingDB

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