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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL136702
Molecular formula	C18H27NO2
IUPAC name	1-[4-[[1-(cyclopropylmethyl)piperidin-4-yl]methoxy]phenyl]ethanol
Molecular weight	289.419
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.9
Synonyms	1-[4-(1-Cyclopropylmethyl-piperidin-4-ylmethoxy)-phenyl]-ethanol BDBM50002308 4-[[4-(1-Hydroxyethyl)phenoxy]methyl]-1-(cyclopropylmethyl)piperidine
Inchi Key	GTKCLGFNNRQQBP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H27NO2/c1-14(20)17-4-6-18(7-5-17)21-13-16-8-10-19(11-9-16)12-15-2-3-15/h4-7,14-16,20H,2-3,8-13H2,1H3
PubChem CID	10085583
ChEMBL	CHEMBL136702
IUPHAR	N/A
BindingDB	50002308
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID1360026	BindingDB,ChEMBL

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