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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL136381
Molecular formula	C18H21FN2O
IUPAC name	4-[[4-[(4-fluorophenoxy)methyl]piperidin-1-yl]methyl]pyridine
Molecular weight	300.377
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.2
Synonyms	4-[(4-Fluorophenoxy)methyl]-1-(4-pyridinylmethyl)piperidine BDBM50002236 SCHEMBL7335232 4-[4-(4-Fluoro-phenoxymethyl)-piperidin-1-ylmethyl]-pyridine;0.25hydrate CHEMBL1180648 ZINC14953 [ Show all ]
Inchi Key	FCTXVIRWLWVYPI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H21FN2O/c19-17-1-3-18(4-2-17)22-14-16-7-11-21(12-8-16)13-15-5-9-20-10-6-15/h1-6,9-10,16H,7-8,11-14H2
PubChem CID	10447534
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50002236
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2753.0 nM	PMID1360026	BindingDB

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