Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil SMR000038923 HMS3393A08 STK368596 Alimoral J10067 Sulpiride [USAN:INN:BAN:JAN] Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida Sulpiridum [INN-Latin] BPBio1_001255 LS-20058 Tox21_302205 CAS-15676-16-1 NCGC00015966-05 Mirbanil Coolspan NCGC00255813-01 N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 Prestwick3_000056 (.+/-.)-Sulpiride Equilid RD 1403 S 8010 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide HMS2231K07 SR-01000075402 Abilit HMS500N20 Sulpirida BCP04500 KS-00000YBQ Sulpiride, SLP BGRJTUBHPOOWDU-UHFFFAOYSA-N Levosulpiridum Sulpride BRD-A55272860-001-08-8 Mariastel Z84655412 CCRIS-4248 NCGC00015966-08 MLS001306443 D01226 NINDS_000278 Dogmatil Oprea1_602476 (+-)-sulpiride DTXSID1042574 PubChem17241 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid FT-0652244 SCHEMBL8421 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 SR-01000075402-6 Aiglonyl IDI1_000278 Sulpiride (JP17/USAN/INN) Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 Sulpiride-R BPBio1_000233 Lopac0_001050 Sursumid C15H23N3O4S NCGC00015966-03 MFCD00055061 NCGC00024852-04 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Nufarol Dolmatil Prestwick1_000056 (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 R. D. 1403 (y)-Sulpiride HMS1568K13 SPBio_002132 676S161 HMS3651G12 Sulperide AN-1017 KB-295026 Sulpiride, British Pharmacopoeia (BP) Reference Standard Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] Sulpitil BRD-A55272860-001-03-9 LS-20059 Tox21_501050 CCG-205127 NCGC00015966-06 Misulvan CS-4534 NCGC00261735-01 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride Omiryl ( inverted question mark)-Sulpiride DSSTox_GSID_42574 Prestwick_431 (?)-Sulpiride EU-0001755 Restful Fardalan S0501 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide HMS3263A22 SR-01000075402-2 AC-12181 HY-B1019 Sulpirida [INN-Spanish] BCP13871 Kylistro SULPIRIDE,(+) Biomol-NT_000037 Levosulpiridum [INN-Latin] Sulpyrid BRN 0494008 MCULE-7506797476 Zemorcon Championyl NCGC00024852-02 MolPort-002-070-475 Darleton Norestran Dogmatyl Ozoderpin (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil Pyrikappl (RS)-(+/-)-sulpiride GTPL5501 Sernevin 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 Stamonevrol AKOS004912732 Isnamide Sulpiride 1.0 mg/ml in Methanol Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid Sulpiridum BPBio1_000463 LP01050 Synedil Calmoflorine NCGC00015966-04 Miradol CHEMBL26 NCGC00024852-05 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Dresent Prestwick2_000056 (+/-)-Sulpiride Enimon R.D. 1403 15676-16-1 HMS2095K13 Splotin AB0105833 HMS3712K13 Sulpirid AN-1019 KBio1_000278 Sulpiride, European Pharmacopoeia (EP) Reference Standard Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] Sulpor BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride Valirem CCRIS 4248 NCGC00015966-07 MLS000069434 CTK8F2082 Neogama N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren Omperan (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 Psicocen (plusmn)-sulpiride EU-0101050 RV-12309 Fidelan s4655 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 SR-01000075402-3 AC1L1K62 I06-0054 BDBM11638 L-Sulpiride SULPIRIDE,(-) Biomol-NT_000162 Lisopiride Suprium BSPBio_000211 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Meresa CHEBI:32168 NCGC00024852-03 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Normum Dogmatyl (TN) Prestwick0_000056 (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl Pyrkappl (RS)-(A+/-)-Sulpiride [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	75.9 nM	PMID2522993	ChEMBL
Kb	319000.0 nM	PMID2522993	ChEMBL
Ki	14.45 nM	PMID2017157	BindingDB
Ki	70.0 nM	PMID2895008	BindingDB

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417