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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	buspirone
Molecular formula	C21H31N5O2
IUPAC name	8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	385.512
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.6
Synonyms	8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)- FT-0621488 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]-butyl]-8-azaspiro[4.5]decane-7,9-dione KBio2_002236 AB00053432-12 MCULE-1919697845 Ansial (TN) NCGC00015162-03 AZA012 NCGC00024905-01 BPBio1_001403 Prestwick3_000369 Buspinol (TN) Spectrum_001756 Buspirone-MDTS CAS-33386-08-2 4332-EP2298765A1 Tox21_302371 DSSTox_CID_2707 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione GTPL36 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione KBioSS_002236 ACM36505847 MRF-0000691 Anxiron NCGC00015162-06 Bespar NCGC00255227-01 BRD-K93461745-003-14-4 SC-77430 Buspirona STK086268 Buspisal CHEBI:3223 ZINC1530571 8-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione DTXSID2022707 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione KB-250161 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione Lopac0_000223 AKOS002313325 NCGC00015162-01 Axoren NCGC00015162-10 Biomol-NT_000108 Prestwick1_000369 Buspar (TN) Spamilan (TN) Buspirone (INN) C13H21NO2.C9H14N4 4332-EP2280008A2 D07593 Tox21_110092 DB00490 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)- Gen-Buspirone 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione KBio2_004804 AB00053432_13 MJ-9022-1 Ansiced NCGC00015162-04 BAS 00928841 NCGC00024905-02 BRD-K93461745-001-01-5 QWCRAEMEVRGPNT-UHFFFAOYSA-N Buspiron Spitomin (TN) Buspironum (buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione CAS-36505-84-7 4332-EP2298776A1 UNII-TK65WKS8HL DSSTox_GSID_22707 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione : (Hydrochloride) HMS2090K19 8-[4-[4-(pyrimidine-2yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7.9-dione L001110 AJ-26666 N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide Anxiron (TN) NCGC00015162-07 Bespar (TN) NINDS_000921 BRN 0964904 SCHEMBL16398 Buspirona [INN-Spanish] Buspisal (TN) 36505-84-7 505B847 TK65WKS8HL 8-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-8-azaspiro[4.5]decane-7,9-dione # EINECS 253-072-2 8-[4-(4-pyrimidin-2-ylpiperazinyl)butyl]-8-azaspiro[4.5]decane-7,9-dione KBio1_000921 AB00053432 LS-22723 Ansial NCGC00015162-02 Axoren (TN) NCGC00016820-01 BPBio1_000547 Prestwick2_000369 Buspimen (TN) SPBio_002418 Buspirone [INN:BAN] C21H31N5O2 4332-EP2298764A1 D0U2OO Tox21_110092_1 DivK1c_000921 8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]- Gen-Buspirone (TN) 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione KBio2_007372 AC1L1DRN MolPort-002-539-709 Ansiced (TN) NCGC00015162-05 BDBM50001859 NCGC00024905-03 BRD-K93461745-003-03-7 SBI-0050211.P003 Buspiron (TN) ST50759566 Buspironum [INN-Latin] CCG-204318 4332-EP2305678A1 W-106606 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione DSSTox_RID_76696 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione; Hydrochloride(Buspirone) IDI1_000921 8-{4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione Lopac-B-7148 AK129737 Narol (TN) AX8227689 NCGC00015162-08 BIDD:GT0519 Prestwick0_000369 BSPBio_000497 Sorbon (TN) C06861 4332-EP2275420A1 CHEMBL49 Tocris-0962 [ Show all ]
Inchi Key	QWCRAEMEVRGPNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
PubChem CID	2477
ChEMBL	CHEMBL49
IUPHAR	36
BindingDB	50001859
DrugBank	DB00490
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
288308	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
288309	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
288307	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
288312	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
288327	5-hydroxytryptamine receptor 1D	P28565	Htr1d	Rattus norvegicus (Rat)	374
288330	5-hydroxytryptamine receptor 1D	P79400	HTR1D	Sus scrofa (Pig)	291
288313	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
288316	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
288320	5-hydroxytryptamine receptor 2A	Q75Z89	HTR2A	Bos taurus (Bovine)	470
288310	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
288315	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
288321	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
556596	5-hydroxytryptamine receptor 4	Q62758	Htr4	Rattus norvegicus (Rat)	406
288325	5-hydroxytryptamine receptor 6	Q9R1C8	Htr6	Mus musculus (Mouse)	440
554706	5-hydroxytryptamine receptor 7	P32304	Htr7	Mus musculus (Mouse)	448
554707	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
288323	Alpha-1A adrenergic receptor	P18130	ADRA1A	Bos taurus (Bovine)	466
453070	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
288326	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
288328	Alpha-2A adrenergic receptor	Q28838	ADRA2A	Bos taurus (Bovine)	452

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